Has anyone written a NEURON model like is described in the paper:
Naundorf, Wolf and Volgushev 2006: Unique features of action potential initiation in cortical neurons ?
This is the recent paper that refutes the Hodgkin-Huxley model and claims that the sodium channels are not independent.
Cooperative sodium channels
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You might want to check ModelDB http://modeldb.yale.edu
With regard to refutation, see
McCormick, D.A., Shu, Y., Yu, Y. (2007) Hodgkin and Huxley model - still standing?
Nature 445: 4 January 2007
and
Shu, Y., Duque, A., Yu, Y., Haider, B., McCormick, D.A. (2007) Properties of action potential
initiation in neocortical pyramidal cells: evidence from whole cell axon recordings.
J. Neurophysiol. 97: 746-760
Both are downloadable from
http://www.med.yale.edu/neurobio/mccormick/pubs.html
So at present the verdict seems to be "not proven." Sustaining the cooperativity hypothesis
will require stronger evidence than what Naundorf et al. presented.
With regard to refutation, see
McCormick, D.A., Shu, Y., Yu, Y. (2007) Hodgkin and Huxley model - still standing?
Nature 445: 4 January 2007
and
Shu, Y., Duque, A., Yu, Y., Haider, B., McCormick, D.A. (2007) Properties of action potential
initiation in neocortical pyramidal cells: evidence from whole cell axon recordings.
J. Neurophysiol. 97: 746-760
Both are downloadable from
http://www.med.yale.edu/neurobio/mccormick/pubs.html
So at present the verdict seems to be "not proven." Sustaining the cooperativity hypothesis
will require stronger evidence than what Naundorf et al. presented.