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Meena

Hi! I was just looking at the paper: http://www.neuron.yale.edu/neuron/papers/NIPS94/nipsfin.html I have a question on defining electrotonic distance in the classical cable theory and in NEURON. 1. When we say electrotonic distance do we mean the distance at which the voltage has reduced to 1/e of i...

Meena

Hi, I have some questions regarding how nseg is determined in NEURON to achieve the best possible accuracy. Some of my questions maybe be basic, but please bear with me. I know from reading the textbook that the d_lambda rule can be used to determine the optimal nseg number. (Page 122). The first fe...

Meena

Hi, I am modelling a soma with nseg=1 and a dendrite with nseg=2. I know from reading the neuron textbook that the nseg governs how the internals nodes are placed. Let's also assume that the soma and dendrites in my model are represented by simple RC circuits. (i)Since the soma has nseg=1, the nodes...

Meena

Hi, I am working on putting together a small document on good tracing techniques and considerations when tracing a cell using Neurolucida. From my reading so far, there is a lot of emphasis on good microscope setup and calibration. Also, there is much stress of the need for shrinkage correction to o...

Meena

Hi again,

I tried deleting nrnmech.dll and any .c and .o files, then running mknrndll,
but that did not work.

I ended up having to remove Neuron and re-installing it but that worked!!!

Thanks so much!
Meena

Meena

Hi, I have Neuron 5.9 already installed in my personal computer - everything runs and works fine. But when I tried installing Neuron 5.9 into another machine and running my files from here, I am prompted with this error: loading membrane mechanisms from nrnmech.dll Undefined symbol _nrnmpi_myid refe...

Meena

Hi Ted, <html>How? Using the Import3D tool? </html> Yes, I used the Import 3D tool <html>Meaning you do exactly what?</html> The first thing I did was to look at the cell in Neurolucida Explorer and find the major and minor axis ( I am assuming the soma can be estimated using a prolate shperoid). Th...

Meena

Hi, I have a question on modelling the cell as a 3D structure in Neuron vs modelling it as cylindrical section. I received a Neurolucida image of cell soma (in .asc format) and converted this into Neuron. I would like to assume the soma as a prolate spheroid as I think this is a reasonable assumptio...

Meena

Hi Ted, Thanks so much but I've looked and looked at it - and found that in my model - (as mentioned I have INaca and ICal and ICap) ica in my model was = ICal - INaca I found this out - by removing one of the currents mech and looking at the ica and the adding the mechanism - as far as adding up go...

Meena

Hi, I am trying to add two mechanisms that will write ica - the sodium calcium exchanger and the long lasting calcium mechanisms to my model. So the first part of the for the Nacax would look like: SUFFIX naca USEION ca READ cai,cao WRITE ica USEION na READ nai,nao WRITE ina and the first part of th...

Meena

Thanks for the pointer Ted & Raj,

It works fine now and I managed to save the data that I was infact hoping to save!

Meena

Hi, I am trying to save the sodium current at the soma in my model in an .asc file. This current would be called soma.i_na(0.5) When I try getting the current profile in Neuron's "current" graph, I have no problem, I see a very small negative ( inward current) on my screen, this is what I ...

Meena

Hi again Ted, Ok, so first thing I did now is to move the point of current injection and voltage measure to the "0" The Vm measured was 50.39mV. The RN is (50.39mV+70mV)/1nA=120.39 Mohm. I guess I have much higher value here than when i injected the current and measured the voltage at the ...

Meena

Hi Ted, I tried this and I am going to take a stab at explanaining it... This cable has surface area of 3143.57 um^2=3.143e-05 cm^2 Setting a g_pas=0.001 S/cm^2 for this structures, implies that the Rm would be 1k ohm.cm^2, or RM = 31.82 Mohm. Applying a current clamp of 1nA for 50ms resulting the V...

Meena

Hi again! Lets say I am trying to investigate the effect of the different holding voltages in a neuron having an active soma and passive dendrites. I control the holding voltage by adjusting the background currents in the model. Can I subject the model to a current clamp, and the look at the voltage...

www.neuron.yale.edu

Search found 31 matches

Classical Cable Theory

d_lambda rule

Questions on Internal Nodes

Neurolucida Tracing

Undefined symbol _nrnmpi_myid referenced from nrnmech.dll

Modelling soma as 3D vs a cylindrical section

Modelling soma as 3D vs a cylindrical section

Adding NaCa and caL to model

Question about saving current data

Effective Membrane Resistance

Effective Membrane Resistance

Effective Membrane Resistance