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Cooperative sodium channels

Posted: Sat Oct 20, 2007 7:50 pm
by JZ
Has anyone written a NEURON model like is described in the paper:

Naundorf, Wolf and Volgushev 2006: Unique features of action potential initiation in cortical neurons ?

This is the recent paper that refutes the Hodgkin-Huxley model and claims that the sodium channels are not independent.

Posted: Sun Oct 21, 2007 11:46 am
by ted
You might want to check ModelDB http://modeldb.yale.edu

With regard to refutation, see
McCormick, D.A., Shu, Y., Yu, Y. (2007) Hodgkin and Huxley model - still standing?
Nature 445: 4 January 2007
and
Shu, Y., Duque, A., Yu, Y., Haider, B., McCormick, D.A. (2007) Properties of action potential
initiation in neocortical pyramidal cells: evidence from whole cell axon recordings.
J. Neurophysiol. 97: 746-760
Both are downloadable from
http://www.med.yale.edu/neurobio/mccormick/pubs.html

So at present the verdict seems to be "not proven." Sustaining the cooperativity hypothesis
will require stronger evidence than what Naundorf et al. presented.