Search found 5 matches

by Dax42
Sun Nov 03, 2013 7:40 pm
Forum: General questions and discussions about computational neuroscience
Topic: measured vs specific Rm
Replies: 7
Views: 22412

Re: measured vs specific Rm

Hi Ted, I am performing patch-clamp experiments and the estimate of tau comes from a depolarisation step. This is a standard protocol called seal test or sometimes membrane test. Thanks for raising a number of interesting points. I am trying to look into action potential backpropagation, hence I was...
by Dax42
Sun Nov 03, 2013 3:09 pm
Forum: General questions and discussions about computational neuroscience
Topic: measured vs specific Rm
Replies: 7
Views: 22412

Re: measured vs specific Rm

Hi Ted, Thanks again for taking time to respond to my questions. The half width of a spike is only about 1 ms, much shorter than membrane time constant Actually, the time constants that I am seeing are on the same order as my AP half widths, around 1.5 ms (measured at the soma, granted). Where exact...
by Dax42
Sun Nov 03, 2013 10:21 am
Forum: General questions and discussions about computational neuroscience
Topic: measured vs specific Rm
Replies: 7
Views: 22412

Re: measured vs specific Rm

Hi Ted, Thanks very much for getting back to me and sorry for not clarifying enough. In myelinated or nonmyelinated axon? Prediction for nonmyelinated axon: Rm has no effect as long as membrane isn't grossly leaky. In nonmyelinated axons. Why do you say that it won't have any effect? Surely tau is g...
by Dax42
Fri Nov 01, 2013 9:28 pm
Forum: General questions and discussions about computational neuroscience
Topic: measured vs specific Rm
Replies: 7
Views: 22412

measured vs specific Rm

Hi all, I would like to see how conduction velocity changes in response to changes in membrane resistance. Not just theoretically though, but using experimentally determined values. From whole-cell voltage clamp experiments I have estimates of the conduction velocity, membrane resistance and membran...
by Dax42
Mon Feb 06, 2006 12:24 pm
Forum: Getting started
Topic: IPSP/EPSP
Replies: 1
Views: 3506

IPSP/EPSP

Hi there, I am a complete newbie to NEURON and just want to replicate some data from a paper. So, I installed NEURON and downloaded the model they are using (Stuart and Spruston, 1998). Everything works fine so far. Now they talk about simulating an IPSP by a conductance change with reversal potenti...