Search found 12 matches

by plasticity
Tue Nov 20, 2018 10:23 pm
Forum: General questions and discussions about computational neuroscience
Topic: tES and suprathreshold E
Replies: 2
Views: 1587

tES and suprathreshold E

In transcranial electric stimulation (TES) the applied E field amplitude at the level of the targeted cortex underneath the electrode is approximately 0.5V/m. Typically not more than 2mA of current is applied at the scalp electrodes to achieve such an E field amplitude. It’s not possible to go much ...
by plasticity
Sat Nov 10, 2018 8:02 pm
Forum: General questions and discussions about computational neuroscience
Topic: Transfer impedance tool
Replies: 1
Views: 1446

Transfer impedance tool

I have been using the impedance tool in neuron and would like to understand it’s origin in more depth than appears in the documentation. In particular I would like a better understanding of how the transfer impedance (as calculated by NEURON) follows from the active cable equation and under what ass...
by plasticity
Tue Nov 06, 2018 3:45 pm
Forum: General questions and discussions about computational neuroscience
Topic: Passive membrane impedance vs voltage-gated conductance
Replies: 5
Views: 2236

Re: Passive membrane impedance vs voltage-gated conductance

Thanks Ted!

What about for pyramidal cells? Can my question be answered definitively for them?

Cheers!
by plasticity
Tue Nov 06, 2018 3:43 pm
Forum: General questions and discussions about computational neuroscience
Topic: Subthreshold spontaneous oscillations
Replies: 5
Views: 2173

Re: Subthreshold spontaneous oscillations

Hi Ted I (a physicist) am a newbie to the detailed understanding of electrophysiology so I really appreciate your feedback! I guess this is what I am trying to get my head around: I am assuming that there presently exists a model for spontaneous oscillations in neurons (spontaneous in a manner simil...
by plasticity
Mon Nov 05, 2018 10:33 pm
Forum: General questions and discussions about computational neuroscience
Topic: Subthreshold spontaneous oscillations
Replies: 5
Views: 2173

Re: Subthreshold spontaneous oscillations

Hi Ted

By intrinsic subthreshold oscillations I mean spontaneous subthreshold oscillations. Presumably the model must account for spontaneous oscillations much differently than oscillations that are forced upon it by an extrinsic source.
by plasticity
Sun Nov 04, 2018 11:20 pm
Forum: General questions and discussions about computational neuroscience
Topic: Passive membrane impedance vs voltage-gated conductance
Replies: 5
Views: 2236

Passive membrane impedance vs voltage-gated conductance

At subthreshold levels of injected current I am guessing that the passive membrane conductance is much greater than the conductance of voltage-gated channels. Is this true? If so then at what transmembrane potential do the voltage-gated conductances start to dominate. Bit of a newbie question!
by plasticity
Sun Nov 04, 2018 5:18 pm
Forum: General questions and discussions about computational neuroscience
Topic: Subthreshold spontaneous oscillations
Replies: 5
Views: 2173

Subthreshold spontaneous oscillations

Some neurons display intrinsic spontaneous subthreshold oscillations. For subthreshold extrinsic (applied) electrical stimuli (current injection or magnetic induction) the HH equations can often be linearized and the solutions of these equations are good predictors in this subthreshold regime. My qu...
by plasticity
Thu Oct 25, 2018 1:23 am
Forum: Getting started
Topic: Frequency response function
Replies: 4
Views: 1620

Re: Frequency response function

Thanks Ted

I will be taking a look very soon. This is great!

Yep, I figured you had spikes on your mind hence my gentle nudge back toward the subthreshold and linear systems.
by plasticity
Wed Oct 24, 2018 10:38 pm
Forum: Getting started
Topic: Frequency response function
Replies: 4
Views: 1620

Re: Frequency response function

Ted

Subthreshold systems are often described by linearized equations. At steady state they will oscillating at the driving frequency of the input current. No spikes are produced. The Fourier transform of the response is called the frequency response of the system.
by plasticity
Wed Oct 24, 2018 8:18 pm
Forum: Getting started
Topic: Frequency response function
Replies: 4
Views: 1620

Frequency response function

Hi

I am new to NEURON. Does it have a means for calculating the frequency response function between input (injected curren) and output (membrane potential) sites for subthreshold stimuli using a linear model?

Thank you!