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Thanks for your response, Ted. These solutions with artificial spiking cells seem very counter-intuitive (to me). I think I should probably switch to single-compartment HH models, where injected current can immediately change the spiking rate of a cell. Thanks!

:-(
The stimulus V is supposed to change continuously during simulation. If I switch conductance-based cell models instead of artificial spiking cells, would there be any way to instantly convert V->F (stimulus to firing rate)?

Hi, folks I am using NetStim() instances to drive activity my IntFire4 neurons with a stimulus V of varying magnitude. The stimulus can change quickly (about every 50 ms), so I am trying to implement variation in spiking rate using NetStim() instances. So, in the beginning of simulation each cell in...

Solved the problem, thank you!

Hello, Can someone give me an advice how to sample a vector f(t) (voltage), which is drawn by NEURON GUI with variable time step? I basically need values of f(t) at equally spaced time points ti for a usual FFT. I tried to export it (pick Vector->save to file) and perform interpolation, so that f(t)...

Got it, I did not insert the pointers. Now it seems to work. Thanks!

Ted, I am going through your example code Extracellular stimulation and recording . When I insert xtra mechanism into a minimal hh model, such as create soma soma { insert hh insert pas insert xtra } access soma I get the following error, when I press Run: nrniv: Segmentation violation near line 20 ...

Many thanks, Ted. Your response is solving the question in full, as always!

Hello, Could anyone give a hint how to efficiently calculate LFP of a multicompartment cell? I know the basic theory, the line source model - take all transmembrane currents and sum them with weights inversely proportional to the distance from electrode. How to implement this in NEURON in a neat way...

From my user's perspective, I am going to stay mainly in hoc because, as Ted pointed out, native NEURON GUI is richer and more versatile than python substitutes I found so far. But I don't see any convenient way to generate publishing-quality plots using NEURON GUI, except pick vector->save in txt f...

Thank you, Uri. I will try your long-term advice and get rid of hoc GUI but retain the hoc computational part.

Hi, Could you please give a hint on how to run existing hoc file which includes some GUI (ses-file) by using Python? I have PyNEURON installed and run my hoc file with from neuron import * h('load_file("mosinit.hoc")') I get the following errors: In [6]: h('load_file("mosinit.hoc"...

How to fish
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I was tinkering around this example for couple of hours trying to understand why it does not work out for me (no synapse potentiation occurs). Finally I found the reason: in provided stdp.mod file, both potentiation (p) and depression (d) parameters were set to zero :)))

Many thanks, Ted, I appreciate your feedback!

Hi, Ted, Thanks a lot for the explanations. Here are the answers to your questions: 1) I think the difference is because membrane is a capacitor and its (somatic) time constant can be quite long. So once the current is injected by IPSC, it can take a while to equilibrate the membrane potential, henc...