Search found 29 matches

by auatai
Tue Jun 29, 2010 12:29 am
Forum: Other questions
Topic: Rounding up a variable
Replies: 1
Views: 1338

Rounding up a variable

Hi,
Is there any function to round up a floating point variable within the hoc code?

thanks and regards
by auatai
Mon May 10, 2010 1:25 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: Setting the basal level for Intracellular Calcium Concentrat
Replies: 22
Views: 17401

Re: Setting the basal level for Intracellular Calcium Concentrat

Sir,

I wanted your opinion on the following. If I want to calculate the depletion of ca in a fixed extracellular volume and i have inserted a L type Ca channel and the cdp mechanism in the section, then, can i proceed in a way similar to that outlined in the thread on Extracellular K accumulation?
by auatai
Fri May 07, 2010 3:59 am
Forum: Adding new mechanisms and functions to NEURON
Topic: intracellular K depletion and extracellular K accumulation
Replies: 12
Views: 5783

Re: intracellular K depletion and extracellular K accumulation

Dear Sir, I was experimenting with the model for potassium accumulation which had been initially discussed in this post. The one in which accumulation is implemented in the ECS alongwith corresponding depletion in ICS. You had helped me out with the framing of the equations controlling ki and ko and...
by auatai
Thu May 06, 2010 4:34 am
Forum: Adding new mechanisms and functions to NEURON
Topic: intracellular K depletion and extracellular K accumulation
Replies: 12
Views: 5783

Re: intracellular K depletion and extracellular K accumulation

Dear Sir, as always, I am STUCK again.Let me tell you what i did to test the model First I implemented Accumulation in ECS, depletion in ICS and diffusion to a constant volume sink using the relations given below ko'=(1e4)*4*ik/(rho*diam*FARADAY)+(ks-ko)/taus ks'=(ko-ks)/taus ki=kx-ko*rho-ks*rhosnk ...
by auatai
Wed May 05, 2010 6:25 am
Forum: Other questions
Topic: How much Ca accumulation can lead to the death of a neuron
Replies: 1
Views: 1256

How much Ca accumulation can lead to the death of a neuron

Hi, I am working on a ca accumulation mechanism which i want to use in modeling pyramidal neurons found in v1 area of cat visual cortex. I would be grateful if someone can tell me or point me in the right direction as to the approximate levels of intracellular calcium concentration that would lead t...
by auatai
Thu Apr 29, 2010 12:35 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: intracellular K depletion and extracellular K accumulation
Replies: 12
Views: 5783

Re: intracellular K depletion and extracellular K accumulation

Thank you sir, Actually, even I by myself had employed similar suggestions as given by you but was not sure whether I was doing it right. Your post has reassured me that I was on the right track. However the behavior is still not as I desired, so I am trying to work out another way of doing it. In c...
by auatai
Mon Apr 26, 2010 3:13 am
Forum: Other questions
Topic: How to find the spike frequency
Replies: 4
Views: 6984

Re: How to find the spike frequency

Hi,

I managed to work it out myself!

Thanks anyway
by auatai
Mon Apr 26, 2010 2:00 am
Forum: Other questions
Topic: How to find the spike frequency
Replies: 4
Views: 6984

Re: How to find the spike frequency

Sir,

Can you please elaborate a little on how to use the record() method.

Is it possible to use this method to calculate the number of spikes generated in distinct time periods and not just the total number of spikes in the entire simulation?

regards
by auatai
Fri Apr 16, 2010 3:55 am
Forum: Adding new mechanisms and functions to NEURON
Topic: intracellular K depletion and extracellular K accumulation
Replies: 12
Views: 5783

Re: intracellular K depletion and extracellular K accumulation

Dear Sir, The Potassium accumulation mechanism is working as desired. Many thanks for the same. Now, moving ahead, my next step is to implement a sink which is attached to the extracellular space(ECS) and sucks out the accumulated K+ from the ECS. However the efficiency of sucking out is to be inver...
by auatai
Thu Apr 15, 2010 1:11 pm
Forum: Other questions
Topic: Simulating multiple neuron models simultaneously
Replies: 2
Views: 1279

Re: Simulating multiple neuron models simultaneously

Thanks Ted,

I'll try to do it some other way
by auatai
Wed Apr 14, 2010 3:44 am
Forum: Other questions
Topic: Simulating multiple neuron models simultaneously
Replies: 2
Views: 1279

Simulating multiple neuron models simultaneously

Hi, I am not sure if this falls into the realm of parellalization so I have posted this query here. I want to know whether it is possible to simultaneously simulate a group of neurons, all of which may not necessarily be connected to each other but they do share the same extracellular space. Also, t...
by auatai
Mon Apr 12, 2010 8:36 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: intracellular K depletion and extracellular K accumulation
Replies: 12
Views: 5783

Re: intracellular K depletion and extracellular K accumulation

Dear Sir,

Thank you once again. I have started understanding NMODL a little better now, all because of you.
by auatai
Mon Apr 12, 2010 5:40 am
Forum: Adding new mechanisms and functions to NEURON
Topic: intracellular K depletion and extracellular K accumulation
Replies: 12
Views: 5783

Re: intracellular K depletion and extracellular K accumulation

Dear Sir, 1. I made the necessary amendments in the kext.mod file as you had suggested. Here is the kext.mod code : Extracellular potassium ion accumulation NEURON { SUFFIX kext USEION k READ ik WRITE ko,ki RANGE fhspace } UNITS { (mV) = (millivolt) (mA) = (milliamp) FARADAY = (faraday) (coulombs) (...
by auatai
Sat Apr 10, 2010 9:01 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: intracellular K depletion and extracellular K accumulation
Replies: 12
Views: 5783

Re: intracellular K depletion and extracellular K accumulation

Thank you sir. I really appreciate the promptness and detail, of the reply
by auatai
Sat Apr 10, 2010 3:00 am
Forum: Adding new mechanisms and functions to NEURON
Topic: intracellular K depletion and extracellular K accumulation
Replies: 12
Views: 5783

intracellular K depletion and extracellular K accumulation

Hi , I am trying to create a mechanism that reads the potassium current ik and computes the values of ki and ko. What i also require is that ik should also be dependent on the newly modified values of ik and ko. The model that I have in mind is a single compartment soma(with a certain initial potass...