temperature and geometry effects

[GTR]

Dear Ted,

My question is if the lack of proper temperature modifications (implementing temprerature dependent rates with Q10 etc.) in the channels of a neuron model can affect the neuron's behaviour in resting state or more generally the neuron's response? e.g. not exhibiting the appropriate voltage properties that are excepted.

The same question regarding the topology and the geometry of a neuron.
Can these two characteristics affect the neuron's soma behaviour?
If I construct only a neuron's body of any type with all the biophysics well implemented (channels etc.) and put a voltage recorder there (e.g. RunControl),should I expect the same properties when I add the neuron's dendrites (with topology,subsets, L,diam,nseg etc. ) and try again to record voltage in the same soma?
Assuming that these dendrites have the same channels as the soma has,is there any likelyhood to get a different resting behaviour in the 'complete' neuron in relation to the 'soma' neuron?

[ted]

My question is if the lack of proper temperature modifications (implementing temprerature dependent rates with Q10 etc.) in the channels of a neuron model can affect the neuron's behaviour in resting state or more generally the neuron's response? e.g. not exhibiting the appropriate voltage properties that are excepted.

Every model has its domain of application. If temperature-dependent mechanisms were
characterized at only one temperature, then the model is valid for that temperature.

The same question regarding the topology and the geometry of a neuron.
Can these two characteristics affect the neuron's soma behaviour?

Yes. This is the very point of a huge body of experimental and modeling literature.