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modeling Electrical Coupling
Posted: Wed Mar 21, 2007 2:01 pm
by davidfourie
I am using the "gap junction" specification from the neuron book to link two neurons (soma and soma1).
Code: Select all
objref g[2]
soma g[0] = new Gap()
soma1 g[1] = new Gap()
soma g[0].loc(0.5) // middle of soma
soma1 g[1].loc(0.5) // middle of soma1
g[0].r = 3
g[1].r = 3
setpointer g[0].vgap, soma1.v(0.5)
setpointer g[1].vgap, soma.v(0.5)
is there any way of adding a delay to this?
Posted: Thu Mar 22, 2007 9:46 am
by ted
DELAY keyword
Posted: Wed May 09, 2007 9:40 am
by davidfourie
The link doesn't give any details of the use of the keyword.
would I declare it in the .mod file of the Gap junction.
Code: Select all
COMMENT
Electrical coupling modelled with a gap junction between the pre and post neruons.
Model is based on Gap Junction in (Carnevale and Hines 2006a)
ENDCOMMENT
NEURON {
POINT_PROCESS elecSyn
POINTER vgap
RANGE r, i
NONSPECIFIC_CURRENT i
}
PARAMETER { r = 1e10 (megohm) }
ASSIGNED {
v (millivolt)
vgap (millivolt)
i (nanoamp)
}
BREAKPOINT { i = (v - vgap)/r }
I have tried to model this gap junction using a NET_RECEIVE block without much success.
I would prefer to use the standard Gap code with a slight delay.
Dave
Posted: Wed May 09, 2007 11:53 am
by hines
The use of explicit DELAY may not be
well founded in a gap junction context.
If you want more delay in the effect
of a soma voltage in one cell due to
a voltage change in another cell via
gap junction coupling, a physically
meaningful way is to add some cable
properties between the soma and the
gap junction.