neuronal response to magnetically induced electric fields

[fabi.pfeif]

Hello everyone,

I would like to model neuronal response from cells in mouse hippocampus to magnetically induced electric fields. Similar to the paper:


Boshuo Wang, Warren M. Grill, Angel V. Peterchev,
Coupling Magnetically Induced Electric Fields to Neurons: Longitudinal and Transverse Activation,
Biophysical Journal,
Volume 115, Issue 1,
2018,
Pages 95-107,
ISSN 0006-3495,
https://doi.org/10.1016/j.bpj.2018.06.004.


To start, I would like to replicate the simulation in the above mentioned paper in NEURON. Specifically, I would like to simulate the response of an HH axon model to an external electric field. I was reading up on the forum entry viewtopic.php?t=4262 where it is described how to apply extracellular stimulation current using electrodes, but I don't understand how/if this can be used to couple an external magnetically-induced electric field in V/m to the neuron (as opposed to extracellular current).

So I would like to ask the community if there is some function implemented in NEURON to simulate the characteristics of magnetically induced electric fields. Thank you very much in advance.

[ted]

if there is some function implemented in NEURON to simulate the characteristics of magnetically induced electric fields

That is not included with NEURON. However, there are a lot of smart NEURON users who are interested in related problems, so maybe one or more of them has already implemented their own code for doing that with NEURON--see the list, at nrn.readthedocs.io, of papers that report work that was done with NEURON. If nobody has done that yet, maybe you could be the first!

[fabi.pfeif]

thank you very much for your reply!
I found a toolbox (NEMO) which includes NEURON and provides the tools I need. However, I tried to compile the given models and ran into an error when using NEURON to compile the .mod files. I have compiled .mod files before, but now the compilation fails with the following message:

C:/nrn/include/nrnrandom.h:6:7: note: old declaration 'Rand* nrn_random_arg(int)'
6 | Rand* nrn_random_arg(int);
| ^~~~~~~~~~~~~~
ProbAMPANMDA_EMS.cpp: In function 'double urand_ProbAMPANMDA_EMS(double*, Datum*, Datum*, NrnThread*)':
ProbAMPANMDA_EMS.cpp:520:40: warning: 'double nrn_random_pick(void*)' is deprecated: non-void* overloads are preferred [-Wdeprecated-declarations]
520 | value = nrn_random_pick(_p_rng);
| ~~~~~~~~~~~~~~~^~~~~~~~
ProbAMPANMDA_EMS.cpp:388:8: note: declared here
388 | double nrn_random_pick(void* r);
| ^~~~~~~~~~~~~~~
ProbAMPANMDA_EMS.cpp:524:22: error: too many arguments to function 'double scop_random()'
524 | value = scop_random ( 1.0 ) ;
| ~~~~~~~~~~~~^~~~~~~
In file included from C:/nrn/include/mech_api.h:19:
C:/nrn/include/scoplib.h:121:8: note: declared here
121 | double scop_random();
| ^~~~~~~~~~~
make: *** [/cygdrive/c\nrn/lib/mknrndll.mak:27: ProbAMPANMDA_EMS.o] Error 1

There was an error in the process of creating nrnmech.dll
Press Return key to exit

I would like to kindly ask, if the community could give me more information on the origin of this error, since I do not understand what went wrong

kind regards

[fabi.pfeif]

###UPDATE###
I manged to compile the files with an older version of NEURON (7.8) :)

[ted]

So changes to nrnivmodl since NEURON 7.8 have interfered with NEMO. Where did you find NEMO and what is the paper that presents this tool? I wonder if its developers would be interested in making it work under the latest version of NEURON, if that doesn't require too much of their effort.