How to realize the Hopf-bifurcation of hh model in NEURON?
Posted: Tue Apr 04, 2023 2:46 am
Hi, after learning the 'hh' model of neuron, I learned that there is a bifurcation of electrical response of neurons by the stimuli of current. When current is inscreasing, the voltage of neuron can change from resting potential to activated state. If the current stimuli is big and long enough, the voltage will be in a periodic activating state(when we stimulate a single neuron. However, if it is stimulated in the neuron netowork, it will be dependant on the excitatory or inhibitory synapses) But when I create a single neuron model using NEURON in Python(I insert built-in 'hh' only), there is no this phenonmenon. Does it mean there is something incorrect? Or what can I do to realize the correct 'hh' model performance?
https://pic.imgdb.cn/item/642bc38a6ea21b9a9e7e387a.gif(This is the gif from wikepedia. And I asked someone who learning neuroscience longer than me. The reply is most neurons will have this phenonmenon even though they may have different ion channels.)
But the model I built in Python, the voltage change of 40 pA stimuli lasted for 0.1ms is like this.
https://pic.imgdb.cn/item/642bc38a6ea21b9a9e7e387a.gif
Then I made the duration to be 1 ms, then it comes to this.
https://pic.imgdb.cn/item/642bc6fc6ea21b9a9ea2f6d6.png
And I tried to increase the value of current, only the amplitude of voltage is increasing.(I also tried to adjust the value of capacitance of membrane) So I wanna ask about this. If there was something I said it wrong, please correct me, thank you very much.
Looking forward to your reply.
https://pic.imgdb.cn/item/642bc38a6ea21b9a9e7e387a.gif(This is the gif from wikepedia. And I asked someone who learning neuroscience longer than me. The reply is most neurons will have this phenonmenon even though they may have different ion channels.)
But the model I built in Python, the voltage change of 40 pA stimuli lasted for 0.1ms is like this.
https://pic.imgdb.cn/item/642bc38a6ea21b9a9e7e387a.gif
Then I made the duration to be 1 ms, then it comes to this.
https://pic.imgdb.cn/item/642bc6fc6ea21b9a9ea2f6d6.png
And I tried to increase the value of current, only the amplitude of voltage is increasing.(I also tried to adjust the value of capacitance of membrane) So I wanna ask about this. If there was something I said it wrong, please correct me, thank you very much.
Looking forward to your reply.