sodium ion accumulation without diffusion
Posted: Tue Dec 20, 2022 5:47 am
Hello all.,
I am a complete beginner to NEURON. I am trying to implement a cell with voltage-gated sodium, calcium, and potassium channels. I have inserted pumps and now focussing on managing ion diffusion across the membrane. I came across this mechanism on modelDB. https://senselab.med.yale.edu/ModelDB/s ... mod#tabs-2
What is 'f' here and how can I decide the initial concentration here, when the initial sodium internal concentration is 10 mM?
I am a complete beginner to NEURON. I am trying to implement a cell with voltage-gated sodium, calcium, and potassium channels. I have inserted pumps and now focussing on managing ion diffusion across the membrane. I came across this mechanism on modelDB. https://senselab.med.yale.edu/ModelDB/s ... mod#tabs-2
Code: Select all
TITLE Sodium ion accumulation without diffusion
NEURON {
SUFFIX nabalan
USEION na READ ina WRITE nai
RANGE nainit,f
}
UNITS {
(mM) = (milli/liter)
(um) = (micron)
FARADAY = (faraday) (coulomb)
PI = (pi) (1)
}
PARAMETER {
nainit = 0.8 (mM)
f = 2.00
}
ASSIGNED {
ina (milliamp/cm2)
diam (um)
}
STATE {
nai (mM) <1e-4>
}
BREAKPOINT {
SOLVE state METHOD sparse
}
INITIAL{
nai=nainit
}
KINETIC state {
COMPARTMENT PI*diam*diam/4 {nai}
~ nai << (-f*ina*PI*diam*(1e4)/(FARADAY))