Adding a Rate to an Ion based on the flux of another Reaction function
Posted: Wed Oct 13, 2021 3:22 pm
Hello,
I am currently working on inserting pump mechanisms, specifically the Na-K ATPase, into a very simple neuron in order to map out the dynamics of the pump before we move to insert the mechanism into a more complex neuron.
Thus far, I have accomplished this by using the MultiCompartmentReaction function, but I have an interesting problem where the rate scheme that I am using is based purely on the concentrations of internal and external Na (as a form of simplification). This means that thus far, only the sodium concentrations are being affected by MultiCompartmentReaction, while the potassium is left out. This should be easy to fix because I could simply apply the molecular ratio of the Na-K exchange, but unfortunately I am unable to find a means to extract the sodium current of the MultiCompartmentReaction.
We are expecting other forms of Na-based exchange pumps such as Na-Ca to be involved in the larger model, so I also can't use ina as the basis. I'd really appreciate for any advice on this matter!
I am currently working on inserting pump mechanisms, specifically the Na-K ATPase, into a very simple neuron in order to map out the dynamics of the pump before we move to insert the mechanism into a more complex neuron.
Thus far, I have accomplished this by using the MultiCompartmentReaction function, but I have an interesting problem where the rate scheme that I am using is based purely on the concentrations of internal and external Na (as a form of simplification). This means that thus far, only the sodium concentrations are being affected by MultiCompartmentReaction, while the potassium is left out. This should be easy to fix because I could simply apply the molecular ratio of the Na-K exchange, but unfortunately I am unable to find a means to extract the sodium current of the MultiCompartmentReaction.
We are expecting other forms of Na-based exchange pumps such as Na-Ca to be involved in the larger model, so I also can't use ina as the basis. I'd really appreciate for any advice on this matter!