Optimization of single cell models
Posted: Fri Apr 05, 2019 11:50 am
Hi,
I am trying to optimize a model of an oscillating single-compartment neuron to get it to oscillate (and "rest") at a specific membrane potential. I've written python code to create a class for my neuron (using Neuron) and then by creating hundreds of thousands of instances of the model with parameters randomized around a set point, I have been to able to find a few oscillating neurons. However, all of these models rest at a membrane potential that is more positive than I would like. Does anyone have any suggestions? I know I need to use optimization but I'm a newbie when it comes to this sort of optimization. What would be the easiest way to do optimization? Are there pre-existing tools, especially ones that work with well with python, or do I need to create my own pipeline?
Thanks,
Dan
I am trying to optimize a model of an oscillating single-compartment neuron to get it to oscillate (and "rest") at a specific membrane potential. I've written python code to create a class for my neuron (using Neuron) and then by creating hundreds of thousands of instances of the model with parameters randomized around a set point, I have been to able to find a few oscillating neurons. However, all of these models rest at a membrane potential that is more positive than I would like. Does anyone have any suggestions? I know I need to use optimization but I'm a newbie when it comes to this sort of optimization. What would be the easiest way to do optimization? Are there pre-existing tools, especially ones that work with well with python, or do I need to create my own pipeline?
Thanks,
Dan