Fitting time constants for EPSPs
Posted: Tue Apr 24, 2012 5:05 pm
Hi,
How do you fit the experimental data on EPSP/IPSP kinetics? I have two time constants from experiment: "rise time" (3 ms) and "half-duration (width at half-amplitude)" (21 ms). I guess using Exp2Syn() mechanism should suffice? It also has two time constants tau1, tau2, but their meaning is slightly different as they are time constants of the two exponents: g ~ (exp(-t/tau2) - exp(-t/tau1)). How do experienced modelers fit EPSP/IPSP data to synapse parameters, and which synaptic mechanism you use?
Thank you!
How do you fit the experimental data on EPSP/IPSP kinetics? I have two time constants from experiment: "rise time" (3 ms) and "half-duration (width at half-amplitude)" (21 ms). I guess using Exp2Syn() mechanism should suffice? It also has two time constants tau1, tau2, but their meaning is slightly different as they are time constants of the two exponents: g ~ (exp(-t/tau2) - exp(-t/tau1)). How do experienced modelers fit EPSP/IPSP data to synapse parameters, and which synaptic mechanism you use?
Thank you!