Channel firing without a current injection

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hallockk
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Joined: Fri Jul 23, 2010 9:02 am

Channel firing without a current injection

Post by hallockk »

Several of my lab members have asked if there's a way in NEURON to fire some HH channels without injecting current using something like Iclamp. Is there?
ted
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Re: Channel firing without a current injection

Post by ted »

hallockk wrote:fire some HH channels
Fire channels?
hallockk
Posts: 43
Joined: Fri Jul 23, 2010 9:02 am

Re: Channel firing without a current injection

Post by hallockk »

I'd like to be able to open an HH channel without externally injecting current. Maybe have a channel that opens and closes at specific time intervals? I haven't spent much time looking at channels that open based on concentration changes; maybe I could fluctuate an external ion concentration as a way of controlling the open and closed channel states.
ted
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Re: Channel firing without a current injection

Post by ted »

Sounds like you want a mechanism with stochastic channel behavior. An example is built into NEURON's demonstration program neurondemo. You can implement new ones for yourself with the Channel Builder. See the Channel Builder tutorials at NEURON's Documentation page http://www.neuron.yale.edu/neuron/docs
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