Adding Ion Channels

Using the graphical user interface to build and exercise models. Includes customizing the GUI by writing a little bit of hoc.
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namkam
Posts: 1
Joined: Mon Apr 01, 2019 2:59 am

Adding Ion Channels

Post by namkam »

Hello,
I am very new to NEURON and I am using it for a research project that involves a very simple model of an action potential, as per:
https://www.youtube.com/watch?v=oTKqTmcP8Pg&t=306s

There is one thing that I cannot figure out, how do I add the parameters that are "Block Na Channel" or "Unblock Na Channel." With regard to the video, I have figured everything out, except that aspect. How do i do so?

Thank you!
Naomi
ted
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Location: Yale University School of Medicine
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Re: Adding Ion Channels

Post by ted »

"Block Na Channel" and "Unblock Na Channel" are not part of NEURON. Besides, they're just labels in a graphical user interface, not the names of parameters. Some third party created the "action potential" folder and is responsible for its contents. Contact that person and see if he or she will share it with you.

If you are writing your own hoc or Python code and want to know how to "block" a particular ion channel, the short answer has two parts. First, it involves setting a conductance parameter to 0. Second, you need to learn more about density mechanisms and point processes--maybe read one or both of these:
* the paper Hines, M.L. and Carnevale, N.T. The NEURON Simulation Environment Neural Computation 9:1179-1209, 1997
or its preprint https://neuron.yale.edu/neuron/static/p ... /nctoc.htm
* the tutorial https://neuron.yale.edu/neuron/static/d ... index.html
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