Appendix E Flagship Opportunity: https://tinyurl.com/HERO20-HHP
Space Radiation Topics: Topic 2. Computational Brain Modeling to Characterize the Effects of Space Radiation Exposure (see further details at above URL)
Specific Research Focus Area
This topic seeks proposals that focus on identifying, based on historical data / prior research, biophysical parameters and structural features that are altered after radiation exposure and to substitute these into computational brain models in patterns reflecting radiation exposure. The model can then be used to interrogate how network activity is altered and its implications on information processing and network stability – i.e. a perturbation analysis. Network firing statistics, ability to maintain oscillations, etc. would represent some of the potential outcome measures.
Due to high complexity of the research required, we encourage cross-discipline collaboration and multi-disciplinary teams, including but not limited to radiation biologists, radiation physicists, computational modelers, neuroscientists, etc.
Ground-based analogs, Computational. Proposers should discuss radiation parameters with the Space Radiation Element prior to proposal submission. Research proposing in vitro and/or in vivo irradiation experiments will be considered non-responsive.
Development of a computational 3D brain model of the hippocampus and/or prefrontal cortex able to characterize and quantify space radiation effects.
Quantification, using the developed model, of space radiation exposure including:
- Dose/Fluence Response Characterization
- Effect of single ions and/or mixed fields (i.e. Proton and HZE)
Identification of thresholds for failure modes.
Validation of the in silico model based on the comparison to historical experimental behavioral results.
Appendix F Omnibus Opportunity: https://tinyurl.com/HERO20-OMNIBUS3
Three different categories
- Applied Investigations
- New Investigator Opportunity (**NEW**)
- Early Career Investigator Opportunity (**NEW**)
We strongly encourage researchers from all career stages to participate as part of our ongoing efforts to broaden the expertise of our research community. Additionally, please distribute to any colleagues that might be interested in responding. Step-1 proposals are due April 30 thru the NASA NSPIRES system (NSPIRES - NASA Research Opportunities Online (nasaprs.com) https://nspires.nasaprs.com/external/). The Element is limited in the specific feedback we can provide regarding proposals but please do not hesitate to contact us with questions. See attached for documentation for Appendix E and F.
The Space Radiation Element Team