Diverging Synapses

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Diverging Synapses

Post by davidfourie »

I don't know if it is possible but can I split a synapse to go to multiple recipient neurons simultaneously.

If it means anything I have a single LP neuron that synapses onto 8 identical PY neurons. I want this to be in parallel.
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Post by ted »

Depends on what "splitting a synapse" means. If it's just garden variety synaptic
divergence, the answer is absolutely. In NEURON, synapses are generally implemented
as point sources of current (called "point processes," but definitely not what physicists
mean by this term) attached to the postsynaptic cell. For continuous transmitter release,
moment-to-moment coupling to some variable in the presynaptic terminal (e.g. Ca or
membrane potential) is done with a "pointer." For spike-triggered synaptic transmission,
coupling is most efficiently accomplished by events. For gap junctions, it is important that
any charge delivered to the postsynaptic cell is matched by an equal charge removed from
the presynaptic cell; this can be done with paired point processes and pointers. These three
methods are illustrated in chapter 10 of The NEURON Book; if you don't have a copy, try
this earlier revision:
http://www.neuron.yale.edu/ftp/ted/book ... xedref.pdf

Another way to implement gap junctions is with the LinearMechanism class, as done by
Migliore et al. in this paper
Migliore M, Hines ML, Shepherd GM (2005) The role of distal dendritic gap junctions
in synchronization of mitral cell axonal output. J Comp Neurosci 18:151-161
Source code is available from ModelDB
http://senselab.med.yale.edu/senselab/m ... odel=43039
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