Search found 17 matches

by plasticity
Fri Jul 16, 2021 11:28 pm
Forum: Other questions
Topic: Rectifying gap junctions
Replies: 1
Views: 32

Rectifying gap junctions

Can NEURON model rectifying gap junctions?
by plasticity
Sun May 16, 2021 5:28 am
Forum: General questions and discussions about computational neuroscience
Topic: Getting started. Again.
Replies: 6
Views: 415

Re: Getting started. Again.

Thanks

I will read the materials and get back to you if I need more before taking the class.
by plasticity
Sat May 15, 2021 2:39 am
Forum: General questions and discussions about computational neuroscience
Topic: Getting started. Again.
Replies: 6
Views: 415

Re: Getting started. Again.

Ted I am looking for references, preferably a book, which covers the models used in NEURON and the mathematics (and physics) underlying those models. I am presently not particularly interested in the source code that implements the underlying mathematics. PS: Pardon the delay. It took longer than I ...
by plasticity
Wed May 12, 2021 7:00 am
Forum: General questions and discussions about computational neuroscience
Topic: Getting started. Again.
Replies: 6
Views: 415

Re: Getting started. Again.

Thank you.

I have read the first few chapters of The Neuron Book. I don’t like to use black box code so how do I learn more about the mathematics and numerical calculations underlying each of the components used to build models with NEURON?
by plasticity
Tue May 11, 2021 8:26 pm
Forum: General questions and discussions about computational neuroscience
Topic: Getting started. Again.
Replies: 6
Views: 415

Getting started. Again.

I introduced myself to NEURON a couple years ago before getting distracted by more macroscopic neuroscience questions. Now I am back to increasing my understanding of the microscopic. I am back to NEURON. I am a physicist and I have done previous reading about the cable equation, the HH equations an...
by plasticity
Tue Nov 20, 2018 10:23 pm
Forum: General questions and discussions about computational neuroscience
Topic: tES and suprathreshold E
Replies: 2
Views: 3739

tES and suprathreshold E

In transcranial electric stimulation (TES) the applied E field amplitude at the level of the targeted cortex underneath the electrode is approximately 0.5V/m. Typically not more than 2mA of current is applied at the scalp electrodes to achieve such an E field amplitude. It’s not possible to go much ...
by plasticity
Sat Nov 10, 2018 8:02 pm
Forum: General questions and discussions about computational neuroscience
Topic: Transfer impedance tool
Replies: 1
Views: 3521

Transfer impedance tool

I have been using the impedance tool in neuron and would like to understand it’s origin in more depth than appears in the documentation. In particular I would like a better understanding of how the transfer impedance (as calculated by NEURON) follows from the active cable equation and under what ass...
by plasticity
Tue Nov 06, 2018 3:45 pm
Forum: General questions and discussions about computational neuroscience
Topic: Passive membrane impedance vs voltage-gated conductance
Replies: 5
Views: 4345

Re: Passive membrane impedance vs voltage-gated conductance

Thanks Ted!

What about for pyramidal cells? Can my question be answered definitively for them?

Cheers!
by plasticity
Tue Nov 06, 2018 3:43 pm
Forum: General questions and discussions about computational neuroscience
Topic: Subthreshold spontaneous oscillations
Replies: 5
Views: 4232

Re: Subthreshold spontaneous oscillations

Hi Ted I (a physicist) am a newbie to the detailed understanding of electrophysiology so I really appreciate your feedback! I guess this is what I am trying to get my head around: I am assuming that there presently exists a model for spontaneous oscillations in neurons (spontaneous in a manner simil...
by plasticity
Mon Nov 05, 2018 10:33 pm
Forum: General questions and discussions about computational neuroscience
Topic: Subthreshold spontaneous oscillations
Replies: 5
Views: 4232

Re: Subthreshold spontaneous oscillations

Hi Ted

By intrinsic subthreshold oscillations I mean spontaneous subthreshold oscillations. Presumably the model must account for spontaneous oscillations much differently than oscillations that are forced upon it by an extrinsic source.
by plasticity
Sun Nov 04, 2018 11:20 pm
Forum: General questions and discussions about computational neuroscience
Topic: Passive membrane impedance vs voltage-gated conductance
Replies: 5
Views: 4345

Passive membrane impedance vs voltage-gated conductance

At subthreshold levels of injected current I am guessing that the passive membrane conductance is much greater than the conductance of voltage-gated channels. Is this true? If so then at what transmembrane potential do the voltage-gated conductances start to dominate. Bit of a newbie question!
by plasticity
Sun Nov 04, 2018 5:18 pm
Forum: General questions and discussions about computational neuroscience
Topic: Subthreshold spontaneous oscillations
Replies: 5
Views: 4232

Subthreshold spontaneous oscillations

Some neurons display intrinsic spontaneous subthreshold oscillations. For subthreshold extrinsic (applied) electrical stimuli (current injection or magnetic induction) the HH equations can often be linearized and the solutions of these equations are good predictors in this subthreshold regime. My qu...
by plasticity
Thu Oct 25, 2018 1:23 am
Forum: Getting started
Topic: Frequency response function
Replies: 4
Views: 2863

Re: Frequency response function

Thanks Ted

I will be taking a look very soon. This is great!

Yep, I figured you had spikes on your mind hence my gentle nudge back toward the subthreshold and linear systems.