www.neuron.yale.edu

How different is "different"? Major qualitative difference, or just a noticeable quantitative difference while overall time course is preserved? More the latter, probably <5% difference in most cases I looked at. Do the recorded data consist of a single stream of values (samples of the me...

Hi, I've been simulating various transcranial magnetic stimulation (TMS) waveforms for extracellular stimulation in NEURON using the xtra.mod file approach written by Ted. Typically, I down-sample a recorded waveform to the time step of my simulation (e.g. 1 µs or 5 µs) in Matlab, and then I use vec...

I'm mostly working with the Blue Brain cell models right now, which are written in templates, so the first approach isn't ideal, but the second one I think could work. I'm also primarily using extracellular stimulation, and bifurcations are a site of depolarization, so I'm worried this might change ...

Okay, that's what I intended to do with the 3rd approach. I think what I'll have to do is save the pt3d coordinates of regions I want to myelinate in vectors, then disconnect/delete these sections from their parent and child sections, create a new myelinated internodal section and a nodal section an...

Hello, I'm working with cortical cell models with realistic morphologies that include the axon and its collaterals, and I'm applying extracellular stimulation via e_extracellular (using the xtra mechanism written by Ted). As is, the cell models are unmyelinated, but I'd like to add myelin to their e...

I see, I thought when they said they measured the "resulting (passive) steady-state voltage change..." that meant removing the active conductances from the model. I tried just doing their same simulation by injecting a 0.01 nA current in the soma for 100 ms and calculating the impedance of...

Thanks for the reply. It looks like the images didn't attach correctly, here are the links: My results: http://imgur.com/lIuT1Sf Mainen figure: http://imgur.com/r24TR7J I got essentially the opposite trend from the paper, with the largest cell, the L5 pyramidal cell, possessing the lowest transfer i...

Hi, I want to use NEURON's Impedance class to calculate steady state transfer impedances from every dendritic or axonal compartment to the soma for a number of cell models. To make sure I'm doing this correctly, I wanted to generate plots identical to the histograms of transfer impedance in Fig. 4 o...