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Thanks for the reply, Ted.
Though I still do not fully understand SEClamp mechanism, it is a good opportunity to understand NEURON detail.

Thanks for your kind reply, Ted. I understood why the model did not activate, well. The reason why I applied short duration biphasic current pulse is that I want to apply a monophasic square pulse of voltage stimulation. (Since I use the value of the activating function, it is right to use IClamp. A...

Dear all, Hi, I have a problem to apply current controlled stimulation. Background is, There are animal experiments, which apply epidural cortical stimulation with 0.2 ms rectangular pulses. And I try to explain excitability patterns through simulations. Thus, I constructed a 3D volume conductor mod...

Dear Ted, I really appreciate your help. Through files that you emailed, I can reproduce "extracellular stimulus" results in Mahmud and Vassanelli, and additionally, it is a good opportunity to understand how to stimulate neurons. Now, I can proceed with an investigation related to modelin...

Thanks for your kind reply, Ted. I agree that applied current (I_app) did not explain extracellular stimulation adequately. However, since I am currently interested in sinusoidal stimulation to the excitatory and inhibitory neurons, I try to reproduce this paper results. I am also simulating other m...

This modified HH equation was from "Differential modulation of excitatory and inhibitory neurons during periodic stimulation", Mahmud et al., 2016 It aims to simulate excitatory and inhibitory neurons (composed of a single compartment) subject to sinusoidal stimulation using varied frequen...

Dear all, I have a simple question. I try to implement a modified HH model using a single compartment, as follows: cm*dV/dt = I_na + I_k + I_l+ I_app where I_app = cm*dVs/dt and Vs is applied voltage. I want to make NMODL for I_app, by modifying IClamp, as follows: COMMENT applied current ENDCOMMENT...

Thanks always, Ted. Now, I can solve my problem : ) ----------------------------------------------------------------------------------- Dear rth, I also check and fix the Pashut code and found same error what you said before. Even after fixing the Pashut code it induced nothing, it might be due to s...

Thanks for your kind explanation, ted.

I have one more question.
I found that the NMODL code is similar with 'a passive leak current' in 9.2 Example in book.
Since tms pulse has opposite direction with leak current, is it reasonable to multiply is = (-1)*k*f rather than is = k*f?

Sorry, I did not answer properly. At each center point of each compartment, applied membrane current is a scalar value. This membrane current is determined by u(x,y,z) which represents axial direction and F(x,y,z) which is electric field at some point p(x,y,z). Then, this membrane current (scalar) w...

Yes, the u(x,y,z) is assigned by axial direction at each center point of each compartment of neuronal model and F is a scalar that depends only on time which is calculated in finite element head model.

And thanks for recommended papers and I have to keep in mind.

Thanks for kind explanation. I studied the NEURON book and related paper for this issue, and understand what is the problem of Pashut code that ted mentioned before (apply MS as a nonspecific leak current .. part). What I am trying to do is, I calculate potential/electrical field using finite elemen...

I ask my question to the authors, but unfortunately they don't give the answer; because they cannot remember it as it is done almost five years ago. There are some ambiguous things to me, so I will be very pleased if you let me know the answers. First, electric field induced by transcranial magnetic...

Thank you for your answer and the recommended paper was very helpful. Since the solution field by transcranial magnetic stimulation (TMS) is electric field, I am decided to use activating function approach. For this, I reference the Pashut 2011 paper and code https://senselab.med.yale.edu/ModelDB/Sh...

Hi, ted I am interested in the effects of brain stimulation to pyramidal cell. So, previously, I calculated stimulus-induced potential fields using FEM and then applied it to each compartment of pyramidal cells using e_extracellular(x). Similarly, I want to apply extracellular stimulation using elec...