Page 1 of 1

NMODL question

Posted: Wed Jun 28, 2006 6:31 pm
by MH
HI!
Once you write code in NMODL can you use the graphical interface to see what you have created? For example, if I made code that is for an L-Type Calcium Current which has d', f11', f12', and ca_inact' then can I insert those equations into the Channel Builder GUI? If so, how?

MH

Re: NMODL question

Posted: Thu Jun 29, 2006 1:55 am
by ted
MH wrote:Once you write code in NMODL can you use the graphical interface to see what you have created?
Yes. Compile the NMODL file, then run NEURON with that directory as the
working directory. The new mechanism will automatically appear in all tools
that are used to manage distributed mechanisms and point processes.
if I made code that is for an L-Type Calcium Current which has d', f11', f12', and ca_inact' then can I insert those equations into the Channel Builder GUI?
No. The ChannelBuilder's palette of equations is limited to "biophysically
realizable forms" such as Boltzmann, Bose-Einstein . . .
If this is insufficient, you may construct vector pairs that sample the
voltage- or ligand-dependence that you need, and tell the ChannelBuilder
to use these as lookup tables.

That said, I should mention that some papers present equations in forms
that appear not to conform with the ChannelBuilder's palette, but upon
closer examination, and with a little algebraic effort, it is sometimes
possible to rearrange terms in a way that makes them compatible.