www.neuron.yale.edu

Hi everyone,

I am willing to build a homeostatic neuron using mod files. It will be a very simple model (only soma with one voltage-gated sodium ion channel and one voltage-gated potassium ion channel).
The goal is to keep the same membrane potential through the whole stimulation by dynamically changing the number of ion channels according to the reading of the membrane potential.

How could i develop this kind of response?

Best regards,

First develop a complete conceptual model that expresses what you are suggesting. This is a mandatory first step.

Are your ion channels voltage-gated? If yes, what is the mathematical description of gating?

Are the Na and K reversal potentials constant, or are they affected by the transmembrane fluxes of [Na] or [K]? If the latter, how does this happen, and what is the mathematical description of these effects?

Will the model cell have a sodium-potassium pump? If yes, what is the mathematical description of the pump-generated transmembrane ion fluxes?

Is the model cell supposed to generate action potentials? If yes, does it spike spontaneously or will the spikes be triggered by injected current? If the latter, is the injected current constant or is it a series of pulses?

What is the mathematical description of your proposed mechanism for "dynamically changing the number of ion channels"?

Answer those questions, and you'll be ready to implement a computational model that may be useful for evaluating your conceptual model.