Modelling of subcellular signalling
Posted: Wed Nov 18, 2020 1:25 pm
Hi,
I am using NEURON to simulate g-protein coupled receptor signalling. I was wondering if there is a specified way in neuron to send information between point process object and distributed membrane mechanisms (for example ion channels).
I have three mechanisms which I would need to have communicating with each other:
point process -> point process -> distributed membrane mechanism
I have not found a way to connect these except by using pointers. But I would only like to have this connection at certain parts of the simulated cell.
When I insert the ion channels with pointer they will occupy a whole compartment although I would only want a segment to be modulated. To solve this, I place the whole connection on each segment but only turn on (by a modulating the single ion channel) on the specific segment I would like to modulate.
This is very elaborate way of avoiding the crash which occurs if all pointers do not have something pointing at it.
Does anyone have another solution for this?
I cannot combine the point_process because they use different solvers, one uses sparse and the other cnexp.
//jofrony
I am using NEURON to simulate g-protein coupled receptor signalling. I was wondering if there is a specified way in neuron to send information between point process object and distributed membrane mechanisms (for example ion channels).
I have three mechanisms which I would need to have communicating with each other:
point process -> point process -> distributed membrane mechanism
I have not found a way to connect these except by using pointers. But I would only like to have this connection at certain parts of the simulated cell.
When I insert the ion channels with pointer they will occupy a whole compartment although I would only want a segment to be modulated. To solve this, I place the whole connection on each segment but only turn on (by a modulating the single ion channel) on the specific segment I would like to modulate.
This is very elaborate way of avoiding the crash which occurs if all pointers do not have something pointing at it.
Does anyone have another solution for this?
I cannot combine the point_process because they use different solvers, one uses sparse and the other cnexp.
//jofrony