Difference between weight vs. reversal potential for synaptic connections
Posted: Sun Dec 09, 2018 2:44 pm
Good afternoon,
This is less of a question about any particular code and more just pertaining to definitions. When creating a NetCon connection using either ExpSyn or Exp2Syn, what is the difference between the .e (reversal potential) as compared to the weight (second to last parameter in the NetCon)? Intuitively, an inhibitory neuron should have a negative weight, but what does that mean for the corresponding reversal potential? To me, it would make sense that if weight=1 and e=-75, then one should get the same results when weight=-1 and e=75.
Sorry if that was a bit drawn out. For the code shown below, you can ignore everything besides the aforementioned weight.
Where AMPA is represented by:
Thank you as always,
Sean Powell
This is less of a question about any particular code and more just pertaining to definitions. When creating a NetCon connection using either ExpSyn or Exp2Syn, what is the difference between the .e (reversal potential) as compared to the weight (second to last parameter in the NetCon)? Intuitively, an inhibitory neuron should have a negative weight, but what does that mean for the corresponding reversal potential? To me, it would make sense that if weight=1 and e=-75, then one should get the same results when weight=-1 and e=75.
Sorry if that was a bit drawn out. For the code shown below, you can ignore everything besides the aforementioned weight.
Code: Select all
OLMCells[0].soma PyramidalCells[0].nclist.append(new NetCon(&v(0.5), AMPA, -40, 1, 0.5))
Code: Select all
objref GABA
OLMCells[0].soma {
GABA = new Exp2Syn(0.5)
GABA.tau1 = 30
GABA.tau2 = 100
GABA.e = -75
}
Sean Powell