First decide what value to use for Q10. If you don't have an experimentally-determined value, try to make a reasonable guess. As a very rough rule of thumb, Q10 is often assumed to be 3. However, this is truly only a crude guess. Chapter 7 in the book Kinetics for the Life Sciences, by H. Gutfreund (Cambridge University Press, 1995), has an eye-opening discussion of temperature effects on reaction rates. Table 7.1 on p.234 of this book (may still be available in paperback for ~$30 and well worth it) lists the Q10s at ~20 deg C that correspond to various activation energies. Quoting from the bottom of that page, "in biological systems, the majority of reactions has a Q10 near 2. Those with lower Q10 are likely to be diffusion controlled and those with a larger Q10 involve entropy effects due to structural rearrangements."Is there any code or tutorial for temperature alignment using a Q10...?
For example, suppose Q10 really is 3, and that the experimentally observed rates were measured at 22 deg C. Add the following items to your code:
Code: Select all
PARAMETER {
Q10 = 3 (1)
Q10TEMP = 22 (degC)
. . .
ASSIGNED {
celsius (degC)
qt (1)
. . .
INITIAL
qt = Q10^((celsius-Q10TEMP)/10)
. . .
PROCEDURE rates(v (mV)) {
taum = temp_insensitive_expression_for_taum / qt
tauh = temp_insensitive_expression_for_tauh / qt
. . .
}