different mechanisms and temperature
Posted: Fri Apr 08, 2016 9:24 am
Dear Ted,
I have a two compartments model. In one of this compartments I inserted two temperature-dependent mechanisms: hh.mod and Na/K pump.
The hh is the classical built in NEURON model. In this model the parameters are setted at 6.3 degC.
The parameters of the Na/K pump model are setted at the experimental temperature of 36 degC.
Both the two mechanisms have the q10 factor, so they would adapt to any temperature choosen in the hoc code.
I noticed that if I run the silulation at celsius=6.3, without stimuli, the membrane potential stays at its rest value.
If I run it at celsius=35 the membrane potential droops at a more negative value.
To avoid this should I increase the leakage current? Would it be reasonable choose differents hh parameters values for the two compartments?
Could be the problem in using models setted at different experimental temperature (even if there is the q10 factor)?
Best Regards
Menica
I have a two compartments model. In one of this compartments I inserted two temperature-dependent mechanisms: hh.mod and Na/K pump.
The hh is the classical built in NEURON model. In this model the parameters are setted at 6.3 degC.
The parameters of the Na/K pump model are setted at the experimental temperature of 36 degC.
Both the two mechanisms have the q10 factor, so they would adapt to any temperature choosen in the hoc code.
I noticed that if I run the silulation at celsius=6.3, without stimuli, the membrane potential stays at its rest value.
If I run it at celsius=35 the membrane potential droops at a more negative value.
To avoid this should I increase the leakage current? Would it be reasonable choose differents hh parameters values for the two compartments?
Could be the problem in using models setted at different experimental temperature (even if there is the q10 factor)?
Best Regards
Menica