www.neuron.yale.edu

Posted: **Wed Mar 01, 2006 9:35 am**

I have a problem with model description language that Gillies
described in part D of the neuron tutorial,I wrote the NMODL code for CaT.mod. in a notepad ,I saved it, I got to the proper directory and "Make nrnmech.dll" to compile the mod files but how can I test it now?do I have to import it to the hoc inerpreter? to neuron GUI? After implementing the CaT code how do I inject a hyperpolarising
current (e.g. current injections at -0.1, -0.2, and -0.3 nA)
in CaT.mod so as to observe the T-type response that Gillies
mentions in the end of part D?How nrnmech.dll will be loaded and in which hoc file do I have to double click?

Thank you in advance!

Posted: **Wed Mar 01, 2006 10:21 am**

To start two ways of loading your new mechanism:

1. Put the nrnmech.dll that you built (it should be in the directory where you have the mod file) in the directory where you want to wite your hoc-code.

2. From the menu in the GUI: file-> load dll and then navigate to your dll.

To use the CaT create a section and then insert CaT

Code: Select all

create soma
access soma
 
  soma { 
insert CaT
}

In the mod-file the name of the mechanism is behind the SUFFIX keyword:

Code: Select all

NEURON {
    SUFFIX CaT
    USEION ca READ eca WRITE ica
    RANGE gmax
}

Now you still have to add a stimulus. For this you can use IClamp which is used elsewhere in the tutorial.

The hoc-file containing the hoc-code can have any name you like.
(The finished tutorial code is provided on the website: http://www.anc.ed.ac.uk/school/neuron/.)