www.neuron.yale.edu

Hi,

I have two questions about voltage clamp method in NEURON.
1) What is major difference between SEClamp and VClamp in Point Process?
2) I set up an anatomically detailed model with passive and active membrane properties along the whole cell. Then I am trying to simulate voltage-clamp experiment on that model. The main thing of this simulation is to measure the clamping current flowing through the voltage-clamp electrode to maintain the somatic membrane potential constant. Does SEClamp or VClamp have any variable representing this clamping current? Otherwise, could you please advice on how to measure it?

Thanks.

magpie wrote:1) What is major difference between SEClamp and VClamp in Point Process?

Read
Use SEClamp instead of VClamp
in the Hot tips area of the Forum.

While you're poking around that part of the Forum, you might encounter some other items of interest.

Does SEClamp or VClamp have any variable representing this clamping current?

Read the relevant entries in the Programmer's Reference. If you are using MSWin, you already have a copy of the Programmer's Reference installed on your PC. If not, go to NEURON's home page
http://www.neuron.yale.edu
and click on the Documentation link.

Thank you very much, Ted.

It works very well.

NEURON does. The chief problem, at least half of the time, seems to be how
to make the mass of documentation accessible to users. The question is
twofold: where to look, and what to look for. Most often, the place to look
is the Programmer's Reference, but again, what to look for? The "Hot tips"
items are great for what they cover, because the explanations go beyond
the tight focus of the individual Programmer's Reference entries, but they
don't cover everything (and probably should't--not every answer to every
question qualifies as a "hot").