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making K+ channel Ca depentent

Posted: Mon Aug 11, 2008 8:15 am
by bcrunning
hi,
Many models contains the sAHP, fAHP channels. In these models calcium ACTIVATES the channel.
How can I describes a K+ channel that is deactivated by calcium? (e.g - as calcium decreased - the K_current increases)
thx.

Re: making K+ channel Ca depentent

Posted: Mon Aug 11, 2008 12:16 pm
by ted
Write down the equations that specify the voltage- and Ca-dependence of your mechanism.
Examine existing mechanisms to find one that comes closest to what you intend.
Modify it to express the exact voltage- and Ca-dependence that you want.
Test it to verify that you got what you wanted.