Inhibition analysis
Posted: Thu Feb 07, 2008 5:00 am
Hi Ted, Michael,
I am trying to look at the inhibition effect (the effect of different weights) from an Inhibitory cell to a target cell (excitatory or inhibitory). There is an inhibitory (GABA synapses) connection between the two cells. And i am looking at the membrane potential mean of the target cell after action potential emission of the inhibitory cell.
(i put also an IClamp in the target cell to active the cell)
And my problem is to choose the synaptic weight?? At which weight should i stop? I thought that the weight should be between 0 and 1...is it true?? What is the real meaning of w?
I thought that when increasing the weight of the connection, the firing rate of my target cell and its postsynaptic activity would decrease. This is the case, but even is i put w = 10000.
Does w = 10000 mean something for a biophysical model??
Could you explain how do you choose the synaptic weight of your connections?
I know that it depends on the number of neurons, synapses and groups of neurons we want to connect, but isn't there any "rule" to start, and more important to have a correct dynamic of cells!!
Thanks in advance for your help,
Sandrine.
I am trying to look at the inhibition effect (the effect of different weights) from an Inhibitory cell to a target cell (excitatory or inhibitory). There is an inhibitory (GABA synapses) connection between the two cells. And i am looking at the membrane potential mean of the target cell after action potential emission of the inhibitory cell.
(i put also an IClamp in the target cell to active the cell)
And my problem is to choose the synaptic weight?? At which weight should i stop? I thought that the weight should be between 0 and 1...is it true?? What is the real meaning of w?
I thought that when increasing the weight of the connection, the firing rate of my target cell and its postsynaptic activity would decrease. This is the case, but even is i put w = 10000.
Does w = 10000 mean something for a biophysical model??
Could you explain how do you choose the synaptic weight of your connections?
I know that it depends on the number of neurons, synapses and groups of neurons we want to connect, but isn't there any "rule" to start, and more important to have a correct dynamic of cells!!
Thanks in advance for your help,
Sandrine.