Synaptic plasticity

A collection of noteworthy items selected by our moderators from discussions about making and using models with NEURON.

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Synaptic plasticity

Post by ted »

NEURON doesn't come with synaptic mechanisms that have built-in plasticity. However, you can use it to implement whatever kind of synaptic plasticity you like. For example: ... model=3815 implements the short term plasticity mechanism described by
Tsodyks M et al. , Pawelzik K, Markram H (1998) Neural networks with dynamic synapses Neural Comput 10(4):821-35
PMID 9573407 ... model=3264 implements the short term plasticity mechanism described by
Varela JA, Sen K, Gibson J, Fost J, Abbott LF, Nelson SB (1997) A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat primary visual cortex. J Neurosci 17:7926-40
PMID 9315911

Chapter 10 of the NEURON Book presents two examples of use-dependent synaptic plasticity. One has use-dependent potentiation governed by the hypothetical reaction scheme

Code: Select all

          1/tau1    1/tau2
precursor ------> G ------> endproduct
where potentiation is proportional to G, and each presynaptic spike suddenly increases precursor by a fixed amount. The other is a synaptic mechanism with saturation of postsynaptic receptors. If you don't have a copy of the book, here's a preprint of chapter 10 ... xedref.pdf

And here is my implementation of STDP based on the description by Bi and Poo
PMID 11283308 ...
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