Hi,
I am attempting to model a Serotonergic Neuron of the Dorsal Raphe Nucleus.
I am using the CHANNEL BUILDER and I want to customize the K+ channel. How would I go about writing my own equations for N∞, IE
N∞ = 1 / 1 + e(VVk)/k.
I also want to specify an equation for τn (tau), IE
τn = αk + βk / cosh((VVk2)/k2.
Thanks for the help!
Customizing Rate Equations In Channel Builder

 Site Admin
 Posts: 5935
 Joined: Wed May 18, 2005 4:50 pm
 Location: Yale University School of Medicine
 Contact:
Re: Customizing Rate Equations In Channel Builder
The Channel Builder limits your palette of equations to what is built into the Channel Builder. Furthermore, for HHstyle gating, you must either use the alpha, beta or the inf, tau formulationcan't mix them.
That said, your formula for the steady state value of n is built into the Channel Builder, so the only problem is what to do about the time constant's voltage dependence. See
importing data from clipboard into ChannelBuilderGateGUI
http://www.neuron.yale.edu/phpbb/viewto ... =16&t=1291
After you have done that, try saving the ChannelBuilder to a ses file and see if the time constant data are preserved in that file.
That said, your formula for the steady state value of n is built into the Channel Builder, so the only problem is what to do about the time constant's voltage dependence. See
importing data from clipboard into ChannelBuilderGateGUI
http://www.neuron.yale.edu/phpbb/viewto ... =16&t=1291
After you have done that, try saving the ChannelBuilder to a ses file and see if the time constant data are preserved in that file.
How many points on the graph should I use?
I have successfully imported my x, y data but I don't understand how the KSchannel uses the data. Does it use the exact data points I import? Or does it make a calculation based on the data points?

 Site Admin
 Posts: 5935
 Joined: Wed May 18, 2005 4:50 pm
 Location: Yale University School of Medicine
 Contact:
Re: Customizing Rate Equations In Channel Builder
Yes and yes. Think "piecewise linear approximation to a continuous function." Interpolation between breakpoints, and flat between /+ inf and the first/last breakpoint.