Conductance values in passive mechanism

Anything that doesn't fit elsewhere.
Post Reply
mganguly
Posts: 29
Joined: Sun May 03, 2015 7:05 pm

Conductance values in passive mechanism

Post by mganguly » Wed Sep 30, 2015 11:35 am

Hi

I wanted to know the basis of the values chosen for the default passive mechanism in NEURON ? (g= 0.001 (S/cm2), e=-70 (mV)). This is different from the leak channel parameters in the HH model ( gl=0.0003 (S/cm2) and el= -54.3 (mV)). Is there any mention of it in the NEURON documentation (or the NEURON book ) ?

Mohit

ted
Site Admin
Posts: 5590
Joined: Wed May 18, 2005 4:50 pm
Location: Yale University School of Medicine
Contact:

Re: Conductance values in passive mechanism

Post by ted » Wed Sep 30, 2015 2:41 pm

Doubtless the numerical value is mentioned. Can you imagine a reason why that value was chosen, or devise a compelling rationale for making a different value the default?

mganguly
Posts: 29
Joined: Sun May 03, 2015 7:05 pm

Re: Conductance values in passive mechanism

Post by mganguly » Wed Sep 30, 2015 4:51 pm

Hi
I am not sure about this but off the top of my head, the conductance in the passive mechanism consists of the leak conductance from the HH mechanism plus the minor conductance from the movement of non specific ions.

Mohit

ted
Site Admin
Posts: 5590
Joined: Wed May 18, 2005 4:50 pm
Location: Yale University School of Medicine
Contact:

Re: Conductance values in passive mechanism

Post by ted » Wed Sep 30, 2015 5:39 pm

I was fishing for something more like this: 0.001 S/cm2 * 1 uf/cm2 = 1 ms. These are perfect default values for constructing examples that correspond fairly closely to mathematical explorations of cable properties, in which time and space and model parameters are "normalized" so that mere arithmetic doesn't intrude on the analysis.

Post Reply