spine resistance debates
Posted: Tue Apr 25, 2017 5:29 pm
There is great variability in spine resistance estimates in different studies and models. Eg Carnevale
in 2013 said
"Notably, our experimental data was closely modeled using a neck resistance of 520 M , similar to the value reported for hippocampal pyramidal neurons (26). "
("Compartmentalization of GABAergic Inhibition by Dendritic Spines" Science 340:759)
whereas in 2015 noted that "experiments showed the mean values of Rneck=27+/-6 M "
("Electrical behaviour of dendritic spines as revealed by voltage imaging Popovic, Carnevale, Rozsa, Zecevic)
these are different areas, ?species, ages, dendritic locations so it may be that both are true (and many more in between as well) but I'm wondering whether there are further considerations for reconciling these vastly different esimates?
in 2013 said
"Notably, our experimental data was closely modeled using a neck resistance of 520 M , similar to the value reported for hippocampal pyramidal neurons (26). "
("Compartmentalization of GABAergic Inhibition by Dendritic Spines" Science 340:759)
whereas in 2015 noted that "experiments showed the mean values of Rneck=27+/-6 M "
("Electrical behaviour of dendritic spines as revealed by voltage imaging Popovic, Carnevale, Rozsa, Zecevic)
these are different areas, ?species, ages, dendritic locations so it may be that both are true (and many more in between as well) but I'm wondering whether there are further considerations for reconciling these vastly different esimates?