MRF on HH voltage curve

Using the Multiple Run Fitter, praxis, etc..
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Han
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Joined: Mon Jul 06, 2020 7:03 pm

MRF on HH voltage curve

Post by Han »

I would like to find values for internal parameters in the standard HH model, like gNa, gK, and gL that will fit a desire voltage curve.
Is it possible to use the MRF to fit the desired voltage curve of the standard HH neuron? I read the MRF examples and still confused if it is possible to do with the MRF.
In this project http://www.mackelab.org/sbi/tutorial/02_HH_simulator/, their Python toolbox find one possible values of gNa and gK to fit the desire voltage curve.

ted
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Re: MRF on HH voltage curve

Post by ted »

Is it possible to use the MRF to fit the desired voltage curve of the standard HH neuron?
Yes. You might find these ModelDB entries interesting:
modeldb.yale.edu/3342
modeldb.yale.edu/3793

Han
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Joined: Mon Jul 06, 2020 7:03 pm

Re: MRF on HH voltage curve

Post by Han »

Thank you Ted for your answer.
I'm novel in using Neuron and the examples you linked are too cumbersome. Is there a simpler example of using the MRF that related to my question? The tutorial on the website doesn't explain how to use an internal variable from a model or how to run the model from MRF.

ted
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Re: MRF on HH voltage curve

Post by ted »

That's all the MultiRunFItter tutorials of which I am aware. The two ModelDB entries are examples of practical application of the MRF to research problems (specifically, fitting a model to experimental results recorded from a spiking neuron). Maybe you'd be interested in BluePyOpt https://www.frontiersin.org/article/10. ... 2016.00017, which is available from https://github.com/BlueBrain/BluePyOpt

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