Page 2 of 2

Re: Neuron code

Posted: Mon Jun 11, 2018 1:24 pm
by ramcdougal
Ion channel genealogy lists 524 NEURON calcium channel models, not all distinct. If you click that link, you'll see them grouped by similarity. Clicking on an individual model (dot) in the figure will load it in the channel details pane on the bottom right. The info tab (opened by default) contains extensive metadata about the model. The traces tab shows how that channel responds to various stimuli.

Once you've found a model that is applicable to your situation and has the kinetics you expect, note the filename, then click through the ModelDB link and find that file.

Put care in choosing which channels you put together in a model. Remember the Hodgkin-Huxley model is for a squid axon in cold temperatures (NEURON defaults to a temperature of 6.3 C). It wouldn't make sense to mix that with a temperature-sensitive mammalian model, because at least one of them would be at an non-physiological temperature.

Re: Neuron code

Posted: Mon Jun 11, 2018 1:39 pm
by ahmed.hamzah
Thank you.The last comment was important.

Re: Neuron code

Posted: Tue Jun 12, 2018 4:43 pm
by ahmed.hamzah
Does the low threshed calcium current model different from squid to the others.

Re: Neuron code

Posted: Wed Jun 13, 2018 10:02 am
by ted
Is it known that squid even have a low threshold calcium current?

Re: Neuron code

Posted: Wed Jun 13, 2018 12:02 pm
by ahmed.hamzah
I would like to use activation mechanism of calcium is similar to that of sodium current channel, so is there a simple way to do that by using the standard HH for sodium to my max. calcium conductance?

Re: Neuron code

Posted: Wed Jun 13, 2018 3:20 pm
by ahmed.hamzah
[Second step: Use your browser to search the hits for the exact string
WRITE nai
or
WRITE ki
Case is important! Avoid any hits that
WRITE Nai
or
WRITE Ki]
can you tell me how ?