How to add Na+ inactivation to Courtemanche et al Am J Physiol 1998 275:H301
Posted: Wed Jul 31, 2019 3:32 pm
I would like to add Na+ inactivation to the sodium calcium exchanger mod file - https://senselab.med.yale.edu/ModelDB/M ... l?id=88209 - which is based on Courtemanche et al Am J Physiol 1998 275:H301. NCX can inactivate during high intracellular Na+ levels and I would like to experiment with how this alters input-output transformation in various cells. However, I'm unsure how to tackle this (I'm very new to Neuron but experienced Python programmer). It appears that adding a state variable to the model that represents the inactivation state by nai (both cai and nai are already READ in the model) would be required and then solving the rate of inactivation in a Breakpoint statement based on the time dependence of inactivation would be the way to go, but I wanted to know if I was on the right track? and secondly, I wanted to inquire (mainly out of curiosity) if this could also be tackled using Python from within the main init.py file? thanks in advance for any help