One of the interesting points of Tsodyks-Markram model is the possibility to include facilitation,
This way three states are defined
x=> fraction of available synaptic resources but not active
y=> fraction or active synaptic resources
z=> fraction of inactive resources.
y converts to z with time constant t1, and z converts back to x with time constant trec
I want to study the non-facilitated problem and for that
I assume new y0 = y0 + x instead of new y0 = y0 + x · u with u the facilitation term. this because It results a very good and more realistic approach to study of the GABAA dynamics. than just one mono-exponential.
However, since this is a multi-state approach the total time of activation should be comparable with the tau in the mono-exponential case for the limit case, but I can not figure out how to set conditions for that limit case:
Should I assume that trec dominates the dynamics of the channel? or is it somehow a combination between t1 and trec?
Thanks a lot for any feedback!!
Discussions of particular models.
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If you are using my implementation of that mechanism, all that is necessary is to set tau_facil to 0. Then the constant parameter U controls the fraction of x ("available transmitter") that is "released." If you want all of it to be released, just set U to 1.OJAG wrote:I want to study the non-facilitated problem and for that
I assume new y0 = y0 + x instead of new y0 = y0 + x · u with u the facilitation term.
The synaptic conductance decays with a single time constant: tau_1. tau_rec merely governs the rate at which the amount of "available transmitter" is restored.Should I assume that trec dominates the dynamics of the channel? or is it somehow a combination between t1 and trec?