Frankenhaeuser and Huxley model with Anodal Break Excitation

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PhDstudent
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Joined: Mon May 23, 2011 4:12 pm

Frankenhaeuser and Huxley model with Anodal Break Excitation

Post by PhDstudent » Tue May 24, 2011 10:47 am

Hi,

I'm interested in simulating anodal break excitation. I know it's very straightforward with the Hodgkin-Huxley model given a hyperpolarizing pulse with a suitably long duration. However, I'm looking to understand this phenomenon with a Frankenhaeuser-Huxley model, as my experimental preparation is the Xenopus.

I haven't come across any modelling publications demonstrating anodal break excitation with FH equations, but many papers examine it experimentally in various animal preparations - suggesting that it is feature common to excitable membranes, including Frankenhaeuser and Widen (1956) with a desheathed frog nerve. Frankenhaeuser and Widen (1956) showed anodal break excitation with fibres that had experienced some form of damage.

Does anyone have experience or know of any publications using FH equations to generate anodal break excitation?

Thank you in advance for your help and insights!

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