synaptic current that changes with each NetStim

NMODL and the Channel Builder.
Post Reply
fsaraga

synaptic current that changes with each NetStim

Post by fsaraga »

I would like to create a synaptic current (say GABAergic) that changes its maximal conductance, within a small range, each time NetStim is on. This way, the amplitude of the postsynaptic current has some variability each time the synapse is stimulated by NetStim. I have three synapses right now and I can assign each of them a random maximal conductance within a specific range but when I try to make it change as I am stimulating at 5 Hz, the values do not change. This is what I have so far that assigns the random conductance to the 3 synapses:

objref r
r=new Random()
r.uniform(0.0004, 0.0006)
for i=0,2 GABAA_S.g=r.repick()

Is there an easy way to get the synapses to repick from the range each time a presynaptic spike comes in?
ted
Site Admin
Posts: 6300
Joined: Wed May 18, 2005 4:50 pm
Location: Yale University School of Medicine
Contact:

Stochastic variation of peak synaptic conductance

Post by ted »

Good question. Here are several working examples of synaptic mechanisms that
display trial-to-trial fluctuation:
http://www.neuron.yale.edu/phpBB2/viewt ... 08acb111d3
Post Reply