www.neuron.yale.edu

I am working on model of soam using three different voltage gated channels Na,K and Ca, three different leak channels and three different channels of pump for the same ion. I am trying to use theses channels to get a resting value of concentrations after injecting it with certain current u=in the mi...

After adding this condition to the na/K pump BREAKPOINT { inapump = ipumpmax*(1/(1 + pow(km/nai,n))) if(nai <= 10 ){ inapump = 0 }else{ inapump = ipumpmax*(1/(1 + pow(km/nai,n))) } ina = 3.0*inapump if(ki >= 140 ){ inapump = 0 }else{ inapump = ipumpmax*(1/(1 + pow(km/nai,n))) } ik = -2.0*inapump } T...

Thanks for those information. I used that Nadifl.mod in my file.hoc. regarding to the Nadifl.mod, does that file included calculate diffusion and migration terms, that is , {diffusion constant *delta(concentration)/dlta(x)}+{mobility * concentration* delta(poteial )/delta (x)} or just {diffusion con...

Once again thank you. The concentrations has been calculated at nadifl, kdifl and cadifl .mod , so do I have to add the concentrations calculation in the same pump file or I can do it separately like what I did. Secondly, after doing your correction to the code I still have problem with potassium co...

Thank you for replay, the flowing are the file.hoc nad pump.mod Which I used in my code. [create soma soma { nseg = 101 L = 100// [µm] length diam = 0.1 // [µm] diameter insert hh gnabar_hh = 0.120 // [S/cm^2] gkbar_hh = 0.036 // [S/cm^2] glbar_hh = 0.0000 // [S/cm^2] //gcabar_hh = 0.12 // [S/cm^2] ...

I am trying to simulate soma with sealed ends. I have used three ions Na, K and Ca, and injected current was 50 pA for 0.2 ms duration the length of this soma 100 micro-meter and diam=0.1 micrometer. I used three voltage gated channels for Na,K and Ca and Na/K pump. I am trying to find the concentra...

[Second step: Use your browser to search the hits for the exact string
WRITE nai
or
WRITE ki
Case is important! Avoid any hits that
WRITE Nai
or
WRITE Ki]
can you tell me how ?

I would like to use activation mechanism of calcium is similar to that of sodium current channel, so is there a simple way to do that by using the standard HH for sodium to my max. calcium conductance?

Does the low threshed calcium current model different from squid to the others.

Thank you.The last comment was important.

So in this case I have to create file.mod to calculate calcium current . Is there example I can use it for this purpose ?

Thank you Ted. I am trying to add calcium to my code but when drew the calcium concentration with time there is no curve show up in the graph. insert hh gnabar_hh = 0.120 // [S/cm^2] gkbar_hh = 0.036 // [S/cm^2] glbar_hh = 0.0003 // [S/cm^2] gcabar_hh = 0.32 // [S/cm^2] cm=1 // [uF/cm2] Ra=89.9 //oh...

Anyone can help me to do Na/K restoration process, which pushes the concentrations back to equilibrium, because right now the sodium and potassium go up at a certain time and stay constant. is there mechanism to push them back to the resting value.

thanks for explanation. that means the basic equation is Fick's second law,because I am looking for the differential equation that has been used to find the concentration in nadifl. You can find it here:
https://en.wikipedia.org/wiki/Fick%27s_ ... _diffusion

Did you mean that LONGITUDINAL_DIFFUSION
del C/del t=del2 C/del2 x
so it is just Fick's second law.