Search found 6305 matches

by ted
Wed Jul 26, 2023 9:10 pm
Forum: NetPyNE
Topic: non-uniform distribution of ion channel
Replies: 1
Views: 17061

Re: non-uniform distribution of ion channel

Exactly the same way you'd access any range variable. In hoc secname paramname(x) = somevalue where secname is the name of a section paramname is the name of the range variable you want to access x is normalized distance from the 0 end of the section to any point inside the segment of interest and s...
by ted
Wed Jul 26, 2023 8:50 pm
Forum: MSWin
Topic: Python cannot import neuron library on Windows install
Replies: 7
Views: 18598

Re: Python cannot import neuron library on Windows install

Uninstall NEURON, then reinstall it.
by ted
Mon Jul 24, 2023 11:01 am
Forum: Anatomically detailed models
Topic: Setting RMP according to experimental measurements.
Replies: 5
Views: 18573

Re: Setting RMP according to experimental measurements.

If a model cell is not spontanously active (not firing spikes or having spontaneous subthreshold fluctuations of membrane potential), then 1. If the model cell's concentrations and reversal potentials are all constant, it is fairly straightforward and easy to ensure that the model will have whatever...
by ted
Fri Jul 21, 2023 4:16 pm
Forum: Anatomically detailed models
Topic: Setting RMP according to experimental measurements.
Replies: 5
Views: 18573

Re: Setting RMP according to experimental measurements.

Do these model cells have any mechanisms that affect concentrations of ions or second messengers? Examine the NEURON blocks of the mod files. Do you see any USEION statements that WRITE a concentration?
by ted
Fri Jul 21, 2023 11:26 am
Forum: Anatomically detailed models
Topic: Setting RMP according to experimental measurements.
Replies: 5
Views: 18573

Re: Setting RMP according to experimental measurements.

NEURON allows users to include so much complexity into their models that there's no single initialization strategy that works (let alone "works best") for all models. Particularly difficult are models that 1. have one or more state variables (other than membrane potential) with slow dynami...
by ted
Fri Jul 21, 2023 11:05 am
Forum: Other questions
Topic: Code: Getting Value of Voltage at end of current pulse
Replies: 3
Views: 16265

Re: Code: Getting Value of Voltage at end of current pulse

Sometimes the best way to understand documentation, and avoid analysis paralysis, is to run your own tests. In this case, actually use Vector.record to capture your variable(s) of interest. Also record t. What did you discover? Now let me ask you another question: if you only want to know the value ...
by ted
Wed Jul 19, 2023 1:03 pm
Forum: Other questions
Topic: Code: Getting Value of Voltage at end of current pulse
Replies: 3
Views: 16265

Re: Code: Getting Value of Voltage at end of current pulse

from the programmer's reference Vector.record() notes, it seems to me that the vector does not record all the voltages from the stream of voltages. Hmm, if the documentation of Vector.record is that vague, we need to fix it. Can you point to (or quote) the particular part that led to your question?...
by ted
Tue Jul 18, 2023 1:06 am
Forum: Adding new mechanisms and functions to NEURON
Topic: Extracellular Mechanism and Hodgkin-Huxley
Replies: 10
Views: 26329

Re: Extracellular Mechanism and Hodgkin-Huxley

https://www.neuron.yale.edu/ftp/ted/neuron/stimsphere.zip contains source code for demonstrations of extracellular stimulation of a spherical cell with HH membrane properties in an electric field that induces a linear extracellular potential gradient parallel to the x axis. One implementation is en...
by ted
Thu Jul 13, 2023 1:16 pm
Forum: Other questions
Topic: ImportError when importing the unit 'nA' from neuron.units
Replies: 1
Views: 15247

Re: ImportError when importing the unit 'nA' from neuron.units

Yes, nA is not defined in neuron.units, and merely adding
nA = 1
to the list of "NEURON's default units" in the units.py file fixes the problem.

On my machine, units.py is in ~/.local/lib/python3.8/site-packages/neuron
by ted
Wed Jul 12, 2023 3:49 pm
Forum: MSWin
Topic: Nemo-TMS model generation failure
Replies: 6
Views: 18197

Re: Nemo-TMS model generation failure

None of those are distributed with NEURON itself. My guess is they're generated by other code that is part of SimNIBS. You need to ask the developers/maintainers of SimNIBS for help.
by ted
Wed Jul 12, 2023 12:23 am
Forum: MSWin
Topic: Nemo-TMS model generation failure
Replies: 6
Views: 18197

Re: Nemo-TMS model generation failure

Ah, Shirinpour et al. 2021. Something Hananeia, Jedlicka et al. were working on. What version of NEURON was running on the older computer, and what version is running on the new one? a few files of code missing from the NEURON folder in the model generation What files would those be? What error mess...
by ted
Wed Jul 12, 2023 12:14 am
Forum: MSWin
Topic: Nemo-TMS model generation failure
Replies: 6
Views: 18197

Re: Nemo-TMS model generation failure

The first URL points to stuff that doesn't mention NEURON at all.

The second points to something at documentcloud.adobe.com that returns a
URL provided is expired or invalid.
error message.

Is there a published article, even a pdf at bioRxiv, that says something about this?
by ted
Tue Jul 11, 2023 6:48 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: Extracellular Mechanism and Hodgkin-Huxley
Replies: 10
Views: 26329

Re: Extracellular Mechanism and Hodgkin-Huxley

2kV/m E-field magnitude For a model of a 5 um diam spherical cell with hh membrane properties, I'm getting 3.14522 kV/m; for a 10 um diam cell it's half as much (as expected). With extracellular potential gradient 0, rheobase to 4.5 places is 0.0017373 nA, and comparing the resulting trace with the...
by ted
Tue Jul 11, 2023 5:38 pm
Forum: MSWin
Topic: Nemo-TMS model generation failure
Replies: 6
Views: 18197

Re: Nemo-TMS model generation failure

I am unaware that SimNIBS does anything with NEURON. Can you point me to a reference that says something about this?

Even so, given that the symptom is failure of SimNIBS, why not ask the developers/maintainers of SimNIBS for help, e.g. at the GitHub repo for SimNIBS?
by ted
Mon Jul 10, 2023 1:59 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: Extracellular Mechanism and Hodgkin-Huxley
Replies: 10
Views: 26329

Re: Extracellular Mechanism and Hodgkin-Huxley

why does the transmembrane voltage even react if I play a non-zero amplitude pulse through e_extracellular, but never do anything with it? Good question. I bet you can figure this out for yourself with a toy example. Consider a model that consists of two adjacent segments. Draw the equivalent circu...