www.neuron.yale.edu

Can NEURON model rectifying gap junctions?

Thanks

I will read the materials and get back to you if I need more before taking the class.

Ted I am looking for references, preferably a book, which covers the models used in NEURON and the mathematics (and physics) underlying those models. I am presently not particularly interested in the source code that implements the underlying mathematics. PS: Pardon the delay. It took longer than I ...

Thank you.

I have read the first few chapters of The Neuron Book. I don’t like to use black box code so how do I learn more about the mathematics and numerical calculations underlying each of the components used to build models with NEURON?

I introduced myself to NEURON a couple years ago before getting distracted by more macroscopic neuroscience questions. Now I am back to increasing my understanding of the microscopic. I am back to NEURON. I am a physicist and I have done previous reading about the cable equation, the HH equations an...

Thanks, Ted!

In transcranial electric stimulation (TES) the applied E field amplitude at the level of the targeted cortex underneath the electrode is approximately 0.5V/m. Typically not more than 2mA of current is applied at the scalp electrodes to achieve such an E field amplitude. It’s not possible to go much ...

I have been using the impedance tool in neuron and would like to understand it’s origin in more depth than appears in the documentation. In particular I would like a better understanding of how the transfer impedance (as calculated by NEURON) follows from the active cable equation and under what ass...

Thanks Ted!

What about for pyramidal cells? Can my question be answered definitively for them?

Cheers!

Hi Ted I (a physicist) am a newbie to the detailed understanding of electrophysiology so I really appreciate your feedback! I guess this is what I am trying to get my head around: I am assuming that there presently exists a model for spontaneous oscillations in neurons (spontaneous in a manner simil...

Hi Ted

I am not sure that answers my question.

Hi Ted

By intrinsic subthreshold oscillations I mean spontaneous subthreshold oscillations. Presumably the model must account for spontaneous oscillations much differently than oscillations that are forced upon it by an extrinsic source.

At subthreshold levels of injected current I am guessing that the passive membrane conductance is much greater than the conductance of voltage-gated channels. Is this true? If so then at what transmembrane potential do the voltage-gated conductances start to dominate. Bit of a newbie question!

Some neurons display intrinsic spontaneous subthreshold oscillations. For subthreshold extrinsic (applied) electrical stimuli (current injection or magnetic induction) the HH equations can often be linearized and the solutions of these equations are good predictors in this subthreshold regime. My qu...

Thanks Ted

I will be taking a look very soon. This is great!

Yep, I figured you had spikes on your mind hence my gentle nudge back toward the subthreshold and linear systems.