Search found 10 matches

by moeskiski
Tue Jul 17, 2018 12:17 pm
Forum: Anatomically detailed models
Topic: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between them
Replies: 15
Views: 2103

Re: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between t

Hello Ted, Over the past couple of weeks, I've abandoned my previous model completely and have shifted my focus slightly (as I'll outline at the end of the post). Instead of working from the code first, I began designing my model from the GUI. Initially, I used neuromorpho models of pyramidal cells ...
by moeskiski
Thu Jun 28, 2018 5:16 pm
Forum: Anatomically detailed models
Topic: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between them
Replies: 15
Views: 2103

Re: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between t

Unconvincing. Nobody designs models that way. Your latest plots don't show v in cell 1's soma, and words are no substitute for results. If cell 1 is going to have synapses with stdp, it's important that those synapses "know" when the cell spikes. There's a problem with cell 1 and it needs to be dia...
by moeskiski
Wed Jun 27, 2018 6:33 pm
Forum: Anatomically detailed models
Topic: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between them
Replies: 15
Views: 2103

Re: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between t

I'll be curious to know. NEURON comes with current and voltage clamp models, but those are intracellular point sources of current. Some modelers have developed ways to represent extracellular electrical stimulation, which can affect an area, but that's not built into NEURON. https://www.ncbi.nlm.ni...
by moeskiski
Tue Jun 26, 2018 2:57 pm
Forum: Anatomically detailed models
Topic: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between them
Replies: 15
Views: 2103

Re: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between t

Model code developed by others is useful for learning programming by example, and can be a source of reusable components for new model development. It can also be a good starting point if your aim is to pursue a hypothesis that is similar to the one that the model's authors addressed. However, ther...
by moeskiski
Thu Jun 21, 2018 6:27 pm
Forum: Anatomically detailed models
Topic: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between them
Replies: 15
Views: 2103

Re: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between t

You mean a myelinated axon? Very easy. Just create and connect a bunch of node and internode sections with appropriate physical dimensions and membrane properties. The literature is full of them. Have you looked in ModelDB? Yup. I found a lot of different models in modelDB but had trouble understan...
by moeskiski
Tue Jun 19, 2018 8:13 pm
Forum: Anatomically detailed models
Topic: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between them
Replies: 15
Views: 2103

Re: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between t

Then you'll know that the mechanism of ultrasound stimulation is yet unknown, but candidates include direct effects on ion channels or some transient alteration of membrane properties. In either case, it isn't going to be electrical extracellular stimulation, so there's no particular reason to reus...
by moeskiski
Sat Jun 16, 2018 8:39 am
Forum: Anatomically detailed models
Topic: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between them
Replies: 15
Views: 2103

Re: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between t

Exactly what hypothesis is it intended to address? So, I feel it would be useful to show you the abstract of my proposal for a clearer picture. Here it is: "Neuromodulation is a useful approach in therapeutic as well as experimental applications that require the stimulation or inhibition of nerves1...
by moeskiski
Fri Jun 15, 2018 1:04 pm
Forum: Anatomically detailed models
Topic: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between them
Replies: 15
Views: 2103

Re: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between t

In addition to the text editors that ted mentioned, consider Visual Studio Code. It's free and runs on all platforms. More importantly for NEURON: the first time you open a HOC or MOD file, it will prompt you to install an extension that provides NEURON syntax highlighting. I definitely will, Thanks!
by moeskiski
Fri Jun 15, 2018 1:03 pm
Forum: Anatomically detailed models
Topic: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between them
Replies: 15
Views: 2103

Re: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between t

First off, thank you for the very quick response! Why do they need myelinated axons? Is some aspect of the structure or function of myelinated axons essential for the hypothesis that you plan to evaluate with your model? What I'm doing is making a simulation of fiber tract stimulation. I decided to ...
by moeskiski
Mon Jun 11, 2018 6:34 am
Forum: Anatomically detailed models
Topic: Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between them
Replies: 15
Views: 2103

Making whole cells out of Mcintyre myelinated axon model (2002) and testing short and long-term plasticity between them

Hello, I am very new to programming, computation, and mathematics (dynamics and statistics). I'm currently developing a detailed model of 2 (up to 5) connected neurons that need to have myelinated axons. I will stimulate an axon at a single Node of Ranvier in its center to elicit action potentials i...