Search found 6 matches

by BoshuoW
Wed May 03, 2017 1:36 pm
Forum: Other questions
Topic: Intracellular resistance and potentials
Replies: 10
Views: 4838

Re: Intracellular resistance and potentials

Sorry for not being clear. Since I was using the default HH channels in NEURON, I indeed meant the HH.mod file distributed with NEURON, which I located under the folder: \src\nrnoc. Thanks for clarifying the vtrap function and continuity requirement. I thought that the 1e-6 band was narrow enough th...
by BoshuoW
Thu Apr 27, 2017 10:39 am
Forum: Other questions
Topic: Intracellular resistance and potentials
Replies: 10
Views: 4838

Re: Intracellular resistance and potentials

Ted, thank you for the suggestion!! I have doubted the HH.mod file as well, but wasn't very confident to change it. After all, this is the first time I worked with hoc code. I have adjusted the .mod file and the problem has been resolved even without using LinearMechanism. Thresholds could be obtain...
by BoshuoW
Tue Apr 25, 2017 1:43 pm
Forum: Other questions
Topic: Intracellular resistance and potentials
Replies: 10
Views: 4838

Re: Intracellular resistance and potentials

I implemented the model with LinearMechanism, and unfortunately the S-D curve was pretty much identical compared to before. Therefore, I don't think that the very low axial resistance was the problem, but something else contributed to the behavior with short pulse duration and small time steps.
by BoshuoW
Fri Apr 14, 2017 2:57 pm
Forum: Other questions
Topic: Intracellular resistance and potentials
Replies: 10
Views: 4838

Re: Intracellular resistance and potentials

I have actually tried this "spoke-hub" topology as well. The results were almost identical as the other topology, with the same issue for short pulses. Although, I have not experimented so much with changing Ra (set only to 1e-3) or the section's size (set to cylinders of equal length and diameter f...
by BoshuoW
Thu Apr 13, 2017 4:04 pm
Forum: Other questions
Topic: Intracellular resistance and potentials
Replies: 10
Views: 4838

Re: Intracellular resistance and potentials

Hello Ted, thanks for your clarification and suggestion!

I'll explore both the Linear Circuit Builder and Linear Mechanism and see whether it works.
by BoshuoW
Thu Apr 13, 2017 11:38 am
Forum: Other questions
Topic: Intracellular resistance and potentials
Replies: 10
Views: 4838

Intracellular resistance and potentials

Hello all! My questions are: 1. How does NEURON handle axial/intracellular resistance in its internal calculation, and how would setting intracellular resistivity/resistance to very small values (Ra<<default) affect the accuracy and stability of the simulation? Could very short pulse duration (<10 u...