Search found 5 matches

by finesniper
Mon Aug 27, 2018 5:17 am
Forum: Optimization
Topic: Fitting the output of the Linear Circuit Builder
Replies: 2
Views: 103

Re: Fitting the output of the Linear Circuit Builder

Thanks for the quick reply! The first part is understood, I could make it work this way. The second part, dealing with the 13 RC components is however not an MRF bug. This happens whether or not I fit anything. This problem persists even if nothing is open, but the LinearCircuitBuilder itself. I hav...
by finesniper
Sun Aug 26, 2018 12:22 pm
Forum: Optimization
Topic: Fitting the output of the Linear Circuit Builder
Replies: 2
Views: 103

Fitting the output of the Linear Circuit Builder

Dear Ted, I encountered a problem when fitting the voltage-response of a node with the multiple run fitter. I could do everything as expected until a certain point, which was the implementation of more than 12 parallel RC components into my reduced circuit. After the 13th, the Linear Circuit Builder...
by finesniper
Fri Jul 28, 2017 1:04 pm
Forum: Other questions
Topic: Current clamp circuit with capacitance compensation
Replies: 3
Views: 4424

Current clamp circuit with capacitance compensation

I am trying to create a current clamp circuit with bridge balance and capacitance neutralization. Luckily I was able to get a version of older demos, including init_r_comp and init_rc_comp3. Further on, my questions will be about init_rc_comp3, as I was unable to fully understand how this circuit wo...
by finesniper
Wed Oct 12, 2016 11:23 am
Forum: Adding new mechanisms and functions to NEURON
Topic: Transient potassium current as leak
Replies: 1
Views: 4635

Transient potassium current as leak

Hi Ted I apologise in advance if my question is being posted in wrong place. My problem concerns a transient potassium current which is extremely low-voltage activated, and I created the MOD file based on my experimental data. So when I want to insert this mechanism into my reconstructed cell, it un...
by finesniper
Thu Jan 14, 2016 12:12 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: Making a delay in the activation of an ionic current
Replies: 1
Views: 4797

Making a delay in the activation of an ionic current

Hello! I am currently doing a model on reproducing the firing of my recordings from interneurons. The main concenpt of this model is to see, how A-type potassium channels creates a delay in the firing, with the appropriate kinetics. In my recordings, the current does not activate until 1-2 ms after ...