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Hi Ted, Happy new year! I have submitted a paper and now get the comment from the reviewer, there is one question about my neuron model that I do not know how to answer. Firstly, let me introduce my neuron model. The model is a myelinated axion. I use extracellular mechanism in the model, and the ex...

Hi Ted, Do you know the whole mod file for pas? I can only find the passive.mod. The localtemp has nothing to do with pas.mod, i just want to use it as a local variable. so that i can define the localtemp for different myelin. in my code, we want to hot some myelin, so the temperature for different ...

Hi Ted, I have searched a mod file named passive, is it the pas model for myelin? and i have changed the code in passive.mod as following TITLE passive membrane channel UNITS { (mV) = (millivolt) (mA) = (milliamp) (S) = (siemens) } NEURON { SUFFIX passive NONSPECIFIC_CURRENT i RANGE g, e, localtemp ...

Hi Ted, Thanks so much for your full and clear explanation about how to define local temperature for hh.mod. Now i meet another question, we want to change the temperature for myelin which I define like this insert pas e_pas = -65 g_pas = 1.5e-5/diam // S/cm2 cm=0.157/(PI*diam) // uF/cm2 fac = q10^(...

Hi Ted, I just confused about the diameter of the myelin, if we name d as diameter of the node, and D is the diameter of the fiber(include the sheath), so is the diameter of the myelin equal D or d? and somebody talks about the thickness of the myelin, what the thickness of myelin means? how does NE...

Thanks very much for the detailed explaination. I have follow your advice and use the Iclamp as stimulation. i am sure the diameter and other geoetry is right but still the result is not exactly linear, the slope is smaller when the diameter is bigger. i found in FH channel(Frankenhaeuser - Huxley c...

hi, i inserted the fh.mod in my nodes, and i want to analysis the conduction speed of the action potential, according to some paper, the relation between conduction speed and the diameter of the fiber is linear. but when i increase the diameter of the fiber to more than 15um, i found the speed is sl...

Sure,I really appreciate your help. It is my pleasure to cite NEURON. thanks.

Many thanks, i use fh.mod. and i have change the global celsius to locatemp according your example. and it work. thanks a lot.

hello Ted,

now i have 21 nodes of Ranvier in my model, i use "forall" to define the temperature, do you know how to define the temperature for one of those nodes while the temperature for the others nodes are the same?

i would like to write my question clearly, Boundary conditions in this case refer to the conditions at the ends of a simulated neuron because i have a fibre model with a finite length. All nodes of Ranvier will use the FH equations to describe the changes in Vm(membran potential), but the end nodes ...

Membrane potential is the difference in potential between the inside of a cell and the extracellular space immediately adjacent to the outside surface of the cell. sorry, my english is not so good, do you mean the membran potential will immediately adjacent to the outside surface of the cell or the...

Hi Ted, i am simulating a extracellular stimulation, the model is a myelined axon with 21 myelins and 21 nodes. The extracellular electric potential is calculated from Comsol. first i get the center coordinate of each segment for all the myelined and nodes in NEURON, this is accroding your "int...

Cheers,now it work, i modify the code like this: x_model.append(xint.c(1,xint.size()-2)) y_model.append(xint.c(1,xint.size()-2)) z_model.append(xint.c(1,xint.size()-2)) the result is correct then, thank you very much.

Hi Ted, i try to save the membrane potential of different points which is function of time to a ascii file. i click the window and then choose the print & file window manager, then select the window which including these potential lines and "print" as ascii. but i open it use wordpad, ...