Lipid Bilayer

Physical System

Membrane with no channels

Model

Capacitor

Simulation

Representation

	create soma

Using the representation

Run NEURON with above spec.

Exercises

1) Run it.

Double the duration and halve the amplitude (injected charge is constant). Note: Multiplying a field editor value by 2 can be done by typing *2 (return) at the end of the value. Divide by 2 by typing /2 (return).

Return the duration and amplitude to their default values (click in the checkmark box with left mouse button). Halve the duration and double the amplitude.

2) Insert passive conductance channels. (In the terminal window type:

insert pas
e_pas = 0
and redo exercise 1.

3) Change the amplitude to 1A (1e9 nA). (The graphs can be automatically rescaled to show the curves by invoking the Graph menu with the right mouse button and selecting the "View=Plot" menu item.)

The model is a poor representation of the physical system in this case.

4) Change the duration to 0.01 ms.

The simulation is a poor representation of the model in this case

Change the number of Points plotted/ms to 100 and dt to 0.01 ms and repeat the run.

5) Increase the amplitude to 1e4 nA, cut the duration to 1e-5 ms, increase Points plotted/ms to 1e5, and let 'er rip.

After a few seconds of eternity, stop the simulation.
Select "Use variable dt" and try again.


NEURON summer course
Copyright © 1998, 1999 by N.T. Carnevale and M.L. Hines, all rights reserved.